Investigational Drug Details
| Drug ID: | D255 |
| Drug Name: | Quinapril |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00881 |
| DrugBank Description: | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] |
| PubChem ID: | 54892 |
| CasNo: | 85441-61-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2=CC=CC=C2C[C@H]1C(O)=O |
| Structure: |
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| InChiKey: | JSDRRTOADPPCHY-HSQYWUDLSA-N |
| Molecular Weight: | 438.5161 |
| DrugBank Targets: | Angiotensin-converting enzyme |
| DrugBank MoA: | Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption.[A184781] This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation.[A184781] Angiotensin II also stimulates production of plasminogen activator inhibitor-1 (PAI-1), increasing the risk of thrombosis.[A1331] Quinaprilat prevents the conversion of angiotensin I to angiotensin II by inhibition of angiotensin converting enzyme, and also reduces the breakdown of bradykinin.[A1329,A1331] Reduced levels of angiotensin II lead to lower levels of PAI-1, reducing the risk of thrombosis, especially after a myocardial infarction.[A1331] |
| DrugBank Pharmacology: | Quinapril is a prodrug of an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension or adjunct in the treatment of heart failure.[A1329,A1331,L8420] Quinapril has a wide therapeutic window and a long duration of action as it is given in doses of 10-80mg once daily.[L8420] |
| DrugBank Indication: | Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure.[L8420] Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.[L8423] |
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