Investigational Drug Details
| Drug ID: | D286 |
| Drug Name: | Dipyridamole |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00975 |
| DrugBank Description: | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) |
| PubChem ID: | 3108 |
| CasNo: | 58-32-2 |
| Repositioning for NAFLD: | Yes |
| SMILES: | OCCN(CCO)C1=NC2=C(N=C(N=C2N2CCCCC2)N(CCO)CCO)C(=N1)N1CCCCC1 |
| Structure: |
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| InChiKey: | IZEKFCXSFNUWAM-UHFFFAOYSA-N |
| Molecular Weight: | 504.6256 |
| DrugBank Targets: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; cGMP-specific 3',5'-cyclic phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Adenosine deaminase; Calcipressin-1; Alpha-1-acid glycoprotein 1 |
| DrugBank MoA: | Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. |
| DrugBank Pharmacology: | Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. |
| DrugBank Indication: | For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L2429 | NCT01444248 | PHASE4 | COMPLETED | NO | 2010-08 | 2012-08-23 | Details |
| L3194 | NCT03738865 | PHASE3 | COMPLETED | YES | 2018-09-27 | 2020-05-22 | Details |
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