Investigational Drug Details
| Drug ID: | D003 |
| Drug Name: | Cetrorelix |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00050 |
| DrugBank Description: | Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur. |
| PubChem ID: | 25074887 |
| CasNo: | 120287-85-6 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O |
| Structure: |
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| InChiKey: | SBNPWPIBESPSIF-MHWMIDJBSA-N |
| Molecular Weight: | 1431.038 |
| DrugBank Targets: | Gonadotropin-releasing hormone receptor; Lutropin-choriogonadotropic hormone receptor |
| DrugBank MoA: | Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner. |
| DrugBank Pharmacology: | Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner. |
| DrugBank Indication: | For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation |
| Targets: | |
| Therapeutic Category: | |
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