Investigational Drug Details
| Drug ID: | D324 |
| Drug Name: | Pilocarpine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01085 |
| DrugBank Description: | A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. |
| PubChem ID: | 5910 |
| CasNo: | 92-13-7 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O |
| Structure: |
|
| InChiKey: | QCHFTSOMWOSFHM-WPRPVWTQSA-N |
| Molecular Weight: | 208.2569 |
| DrugBank Targets: | Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M5 |
| DrugBank MoA: | Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. |
| DrugBank Pharmacology: | Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. Bronchial smooth muscle tone may increase. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Pilocarpine may have paradoxical effects on the cardiovascular system. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Bradycardia and tachycardia have both been reported with use of pilocarpine. |
| DrugBank Indication: | For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0078 | NCT00869856 | PHASE3 | WITHDRAWN | NO | 2009-04 | 2015-06-02 | Details |
| L0282 | NCT04192110 | PHASE4 | WITHDRAWN | NO | 2020-08-11 | 2021-12-09 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title |
|---|