Investigational Drug Details
| Drug ID: | D347 |
| Drug Name: | Domperidone |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01184 |
| DrugBank Description: | A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. |
| PubChem ID: | 3151 |
| CasNo: | 57808-66-9 |
| Repositioning for NAFLD: | Yes |
| SMILES: | ClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2 |
| Structure: |
|
| InChiKey: | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Molecular Weight: | 425.911 |
| DrugBank Targets: | Dopamine D3 receptor; Dopamine D2 receptor |
| DrugBank MoA: | Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting |
| DrugBank Pharmacology: | Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. |
| DrugBank Indication: | For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title |
|---|