Investigational Drug Details
| Drug ID: | D378 |
| Drug Name: | Spirapril |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01348 |
| DrugBank Description: | Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure. |
| PubChem ID: | 5311447 |
| CasNo: | 83647-97-6 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2(C[C@H]1C(O)=O)SCCS2 |
| Structure: |
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| InChiKey: | HRWCVUIFMSZDJS-SZMVWBNQSA-N |
| Molecular Weight: | 466.614 |
| DrugBank Targets: | Angiotensin-converting enzyme |
| DrugBank MoA: | Spiraprilat, the active metabolite of spirapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Spiraprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin. |
| DrugBank Pharmacology: | Spirapril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. By blocking ACE, spirapril decreases angiotensin II which is a vasoconstrictor and inducer of aldosterone. So by inhibiting the enzymes, aldosterone secreation is decreased (so less sodium is reabsorbed) and there is a decrease in vasoconstriction. Combined, this leades to a decrease in blood pressure. |
| DrugBank Indication: | Spirapril is an ACE inhibitor class drug used to treat hypertension. |
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