Investigational Drug Details
| Drug ID: | D404 |
| Drug Name: | Taurine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB01956 |
| DrugBank Description: | Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes.[A31396] This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and meat.[L1058] The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections composed by cristalline amino acids.[FDA label] |
| PubChem ID: | 1123 |
| CasNo: | 107-35-7 |
| Repositioning for NAFLD: | Yes |
| SMILES: | NCCS(O)(=O)=O |
| Structure: |
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| InChiKey: | XOAAWQZATWQOTB-UHFFFAOYSA-N |
| Molecular Weight: | 125.147 |
| DrugBank Targets: | Glutamate receptor ionotropic, NMDA 2B; Glycine receptor subunit alpha-2; Glycine receptor subunit alpha-3; GABA-A receptor (anion channel); Gamma-aminobutyric acid type B receptor subunit 1; Glycine receptor subunit alpha-1; Alpha-ketoglutarate-dependent taurine dioxygenase; Choloylglycine hydrolase |
| DrugBank MoA: | The diet supplements containing taurine function by replacing the missing nutriments in the body. Taurine, as a single agent, presents different functions like substrate for formation of bile salts, cell volume regulation, modulation of intracellular calcium, cytoprotection of central nervous system, etc.[A31398] |
| DrugBank Pharmacology: | The diet supplements containing taurine are formulated as a well-tolerated nitrogen source for nutritional support. Administration of diet supplements regulates the level of plasma amino acid concentration, nitrogen balance, weight and serum protein concentration to reach normal values, thus improving the nutritional status.[FDA label] |
| DrugBank Indication: | The use of diet supplements containing taurine is indicated for the nutritional support of infants and young pediatric patients requiring total parenteral nutrition via central or peripheral routes. The usage of diet supplements containing taurine prevents nitrogen and weight loss or to treat negative nitrogen balance in pediatric patients where the alimentary tract cannot be done through oral, gastrostomy or jejunostomy administration, there is impaired gastrointestinal absorption or protein requirements are substantially increased.[FDA label] |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0367 | NCT01581073 | PHASE3 | COMPLETED | NO | 2012-02-16 | 2018-04-18 | Details |
| L1315 | NCT05944016 | PHASE3 | RECRUITING | NO | 2024-03-25 | 2024-12-16 | Details |
| L5387 | NCT01476475 | PHASE2 | COMPLETED | YES | 2011-11 | 2017-02-10 | Details |
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