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Investigational Drug Details

Drug ID: D408
Drug Name: Terlipressin
Synonyms:
Type: small molecule
DrugBank ID: DB02638
DrugBank Description: Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension which has been found to be effective when norepinephrine fails.
PubChem ID: 72081
CasNo: 14636-12-5
Repositioning for NAFLD: Yes
SMILES: NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Structure:
InChiKey: BENFXAYNYRLAIU-QSVFAHTRSA-N
Molecular Weight: 1227.372
DrugBank Targets: Vasopressin V1a receptor; Vasopressin V1b receptor; Vasopressin V2 receptor
DrugBank MoA: Terlipressin, an analogue of vasopressin, acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
DrugBank Pharmacology: Terlipressin is a medicine similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin. ADH has two main effects in the body. Firstly, it causes narrowing of blood vessels (vasoconstriction), thereby limiting blood flow to a particular area of the body. It also acts on receptors in the kidney to retain water in the body, which helps to prevent excessive loss of water in the urine.
DrugBank Indication: Commonly used to stop bleeding of varices in the food pipe (oesophagus).
Targets:
Therapeutic Category:
Clinical Trial Progress:
Latest Progress: