Investigational Drug Details
| Drug ID: | D041 |
| Drug Name: | Proline |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00172 |
| DrugBank Description: | Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. |
| PubChem ID: | 145742 |
| CasNo: | 147-85-3 |
| Repositioning for NAFLD: | Yes |
| SMILES: | OC(=O)[C@@H]1CCCN1 |
| Structure: |
|
| InChiKey: | ONIBWKKTOPOVIA-BYPYZUCNSA-N |
| Molecular Weight: | 115.1305 |
| DrugBank Targets: | Pyrroline-5-carboxylate reductase 1, mitochondrial; Bifunctional glutamate/proline--tRNA ligase; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Sodium-dependent proline transporter; Pyrroline-5-carboxylate reductase 2; Prolyl 4-hydroxylase subunit alpha-2; Proline dehydrogenase 1, mitochondrial; Peptidyl-prolyl cis-trans isomerase H; Proline synthase co-transcribed bacterial homolog protein; Prolyl 4-hydroxylase subunit alpha-1; Peptidyl-prolyl cis-trans isomerase B; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; Peptidyl-prolyl cis-trans isomerase C; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase G; Prolyl 3-hydroxylase 1; Pyrroline-5-carboxylate reductase; Probable proline--tRNA ligase, mitochondrial; Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase 3; Pyrroline-5-carboxylate reductase 3; Trans-L-3-hydroxyproline dehydratase |
| DrugBank MoA: | Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline via L-Glutamic acid-gamma-semialdehyde. It is contained abundantly in collagen, and is intimately involved in the function of arthrosis and chordae. |
| DrugBank Pharmacology: | L-Proline is a major amino acid found in cartilage and is important for maintaining youthful skin as well as repair of muscle, connective tissue and skin damage. It is also essential for the immune system, and for necessary balance of this formula. It is an essential component of collagen and is important for proper functioning of joints and tendons. L-Proline is extremely important for the proper functioning of joints and tendons. Helps maintain and strengthen heart muscles. |
| DrugBank Indication: | L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0490 | NCT00270426 | TERMINATED | NO | 2006-05-05 | Details | ||
| L1315 | NCT05944016 | PHASE3 | RECRUITING | NO | 2024-03-25 | 2024-12-16 | Details |
| L6345 | NCT01257087 | COMPLETED | YES | 2010-12 | 2020-11-13 | Details | |
| L6419 | NCT01057628 | PHASE3 | COMPLETED | NO | 2010-01-13 | 2024-11-04 | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00001 | 10084598 | J Clin Endocrinol Metab | The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree. | Details |
| A00008 | 10545531 | J Clin Invest | Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. | Details |
| A00017 | 10973253 | Nat Genet | The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. | Details |