Investigational Drug Details
| Drug ID: | D412 |
| Drug Name: | Oxitriptan |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB02959 |
| DrugBank Description: | 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and is also marketed in many European countries for the indication of major depression under trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol, Tript-OH, and Triptum. Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted. More study is needed to determine efficacy in treating depression. |
| PubChem ID: | 439280 |
| CasNo: | 4350-09-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O |
| Structure: |
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| InChiKey: | LDCYZAJDBXYCGN-VIFPVBQESA-N |
| Molecular Weight: | 220.2246 |
| DrugBank Targets: | Tryptophan--tRNA ligase 2 |
| DrugBank MoA: | |
| DrugBank Pharmacology: | The psychoactive action of 5-HTP is thought to be due to increased serotonin production in central nervous system tissue. |
| DrugBank Indication: | For use as an antidepressant, appetite suppressant, and sleep aid. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
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