Investigational Drug Details
| Drug ID: | D414 |
| Drug Name: | Acetylcholine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB03128 |
| DrugBank Description: | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications. |
| PubChem ID: | 187 |
| CasNo: | 51-84-3 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CC(=O)OCC[N+](C)(C)C |
| Structure: |
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| InChiKey: | OIPILFWXSMYKGL-UHFFFAOYSA-N |
| Molecular Weight: | 146.2074 |
| DrugBank Targets: | Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M4; Neuronal acetylcholine receptor subunit alpha-7 |
| DrugBank MoA: | |
| DrugBank Pharmacology: | |
| DrugBank Indication: | Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0044 | NCT02299661 | PHASE1 | COMPLETED | NO | 2014-11 | 2018-12-24 | Details |
| L0272 | NCT03223883 | PHASE2 | COMPLETED | YES | 2018-06-01 | 2024-10-08 | Details |
| L1365 | NCT01155388 | PHASE3 | TERMINATED | YES | 2011-10-17 | 2022-04-28 | Details |
| L1648 | NCT01167309 | PHASE1 | COMPLETED | NO | 2010-06 | 2025-02-24 | Details |
| L4259 | NCT00543517 | PHASE3 | TERMINATED | NO | 2003-02 | 2015-02-10 | Details |
| L5243 | NCT03620890 | PHASE4 | COMPLETED | YES | 2018-09-04 | 2021-09-16 | Details |
| L5528 | NCT03269799 | PHASE2 | UNKNOWN | NO | 2017-08-30 | 2017-09-01 | Details |
| L5728 | NCT03313752 | PHASE3 | UNKNOWN | NO | 2017-12-01 | 2021-03-03 | Details |
| L5843 | NCT00131287 | PHASE3 | COMPLETED | NO | 2005-07 | 2010-01-05 | Details |
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