Investigational Drug Details
| Drug ID: | D417 |
| Drug Name: | Palmitic Acid |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB03796 |
| DrugBank Description: | A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. |
| PubChem ID: | 985 |
| CasNo: | 57-10-3 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CCCCCCCCCCCCCCCC(O)=O |
| Structure: |
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| InChiKey: | IPCSVZSSVZVIGE-UHFFFAOYSA-N |
| Molecular Weight: | 256.4241 |
| DrugBank Targets: | Alpha-lactalbumin; Peroxisome proliferator-activated receptor alpha; Rhodopsin; Palmitoyl-protein thioesterase 1; Myelin P2 protein; Glycodelin; Hepatocyte nuclear factor 4-gamma; Lipid binding protein; Cytochrome P450 2C8; Trafficking protein particle complex subunit 3; Fatty acid-binding protein TM_1468 |
| DrugBank MoA: | |
| DrugBank Pharmacology: | Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC) which is responsible for converting acetyl-ACP to malonyl-ACP on the growing acyl chain, thus preventing further palmitate generation |
| DrugBank Indication: | |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L1315 | NCT05944016 | PHASE3 | RECRUITING | NO | 2024-03-25 | 2024-12-16 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00194 | 39660790 | J Med Econ | Cost-effectiveness analysis of radiofrequency renal denervation for uncontrolled hypertension in Canada. | Details |
| A00200 | 39804512 | Langenbecks Arch Surg | A hypocaloric protein-rich diet before metabolic surgery improves liver function in patients with obesity and diabetes : A secondary analysis of a randomized clinical trial. | Details |