Investigational Drug Details
| Drug ID: | D419 |
| Drug Name: | Citric acid |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB04272 |
| DrugBank Description: | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. |
| PubChem ID: | 311 |
| CasNo: | 77-92-9 |
| Repositioning for NAFLD: | Yes |
| SMILES: | OC(=O)CC(O)(CC(O)=O)C(O)=O |
| Structure: |
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| InChiKey: | KRKNYBCHXYNGOX-UHFFFAOYSA-N |
| Molecular Weight: | 192.1235 |
| DrugBank Targets: | NA; Aldose reductase; Isocitrate dehydrogenase [NADP]; Beta-lactamase; Beta-lactamase 2; Citrate synthase, mitochondrial; Proto-oncogene tyrosine-protein kinase Src; Ribonuclease pancreatic; Eosinophil cationic protein; Fumarate hydratase class II; 6-phosphogluconolactonase; L-amino-acid oxidase; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Cytochrome c peroxidase; Hepatocyte growth factor-regulated tyrosine kinase substrate; Invasin; Intron-associated endonuclease 1; Short tail fiber protein; Malate dehydrogenase, mitochondrial; N5-carboxyaminoimidazole ribonucleotide mutase; 50S ribosomal protein L4; Carboxypeptidase B; Hexon protein; Riboflavin biosynthesis protein RibF; Beta-fructosidase; Putative stringent starvation protein A; Citrate synthase; RNA 3'-terminal phosphate cyclase; U6 snRNA-associated Sm-like protein LSm6; Pleckstrin homology domain-containing family A member 1; Fe(3+)-binding periplasmic protein; Signal recognition particle receptor FtsY; Nicotinate-nucleotide adenylyltransferase; N utilization substance protein B homolog; Complement component C8 gamma chain; Ribonucleoside-diphosphate reductase subunit beta; Glutamine synthetase 1; Citrate synthase; Prostaglandin F synthase; Adenine phosphoribosyltransferase; Glucose-1-phosphate thymidylyltransferase; Glyoxalase family protein; Laccase domain protein YfiH; Ribose-5-phosphate isomerase A; GMP synthase [glutamine-hydrolyzing]; Inosine triphosphate pyrophosphatase; Lysozyme; Glycerol uptake operon antiterminator regulatory protein; 3-carboxy-cis,cis-muconate cycloisomerase; Pyruvate decarboxylase |
| DrugBank MoA: | |
| DrugBank Pharmacology: | |
| DrugBank Indication: | |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0773 | NCT04197778 | PHASE1 | COMPLETED | NO | 2020-01-06 | 2022-06-08 | Details |
| L2697 | NCT00309192 | PHASE3 | COMPLETED | NO | 2006-04 | 2023-03-14 | Details |
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