Investigational Drug Details
| Drug ID: | D445 |
| Drug Name: | Dapagliflozin |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB06292 |
| DrugBank Description: | Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2[A6757]. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria[A6757]. Dapagliflozin was approved by the FDA on Jan 08, 2014[L6034]. |
| PubChem ID: | 9887712 |
| CasNo: | 461432-26-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1 |
| Structure: |
|
| InChiKey: | JVHXJTBJCFBINQ-ADAARDCZSA-N |
| Molecular Weight: | 408.873 |
| DrugBank Targets: | Sodium/glucose cotransporter 2 |
| DrugBank MoA: | Dapagliflozin inhibits the sodium-glucose contransporter 2(SGLT2) which is primarily located in the proximal tubule of the nephron[A6757]. SGLT2 facilitates 90% of glucose resorption in the kidneys and so its inhibition allows for glucose to be excreted in the urine[A6757]. This excretion allows for better glycemic control and potentially weight loss in patients with type 2 diabetes mellitus[A6757]. |
| DrugBank Pharmacology: | Dapagliflozin inhibits the sodium-glucose contransporter 2(SGLT2) which is primarily located in the proximal tubule of the nephron[A6757]. SGLT2 facilitates 90% of glucose resorption in the kidneys and so its inhibition allows for glucose to be excreted in the urine[A6757]. This excretion allows for better glycemic control and potentially weight loss in patients with type 2 diabetes mellitus[A6757]. |
| DrugBank Indication: | Dapagliflozin is indicated to improve glycemic control in adult patients with type 2 diabetes mellitus along with diet and exercise[Label,A6757,A6758]. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0054 | NCT00338000 | PHASE4 | COMPLETED | NO | 2001-06 | 2011-02-01 | Details |
| L0097 | NCT01049711 | COMPLETED | NO | 2009-11 | 2015-09-29 | Details | |
| L0111 | NCT00501475 | PHASE4 | UNKNOWN | NO | 2007-03 | 2010-07-27 | Details |
| L0118 | NCT03183778 | PHASE4 | COMPLETED | YES | 2018-03-12 | 2021-12-01 | Details |
| L0182 | NCT02875886 | PHASE4 | COMPLETED | NO | 2016-09 | 2018-04-20 | Details |
| L0205 | NCT04365218 | PHASE1 | COMPLETED | NO | 2020-07-22 | 2022-04-21 | Details |
| L0218 | NCT00810732 | PHASE2 | COMPLETED | YES | 2007-05-09 | 2023-07-06 | Details |
| L0222 | NCT00368017 | PHASE2 | TERMINATED | NO | 2006-04 | 2010-11-03 | Details |
| L0233 | NCT01843790 | PHASE2 | COMPLETED | NO | 2013-06 | 2015-09-01 | Details |
| L0331 | NCT00162487 | UNKNOWN | NO | 2002-08 | 2008-10-29 | Details | |
| L0396 | NCT06236672 | COMPLETED | NO | 2023-02-15 | 2024-02-01 | Details | |
| L0400 | NCT02408744 | PHASE1|PHASE2 | COMPLETED | NO | 2009-09 | 2015-04-03 | Details |
| L0433 | NCT02608177 | COMPLETED | YES | 2015-11 | 2018-10-12 | Details | |
| L0442 | NCT00212875 | PHASE2 | COMPLETED | NO | 2005-09 | 2011-05-23 | Details |
| L0445 | NCT02497300 | PHASE2 | COMPLETED | YES | 2015-03 | 2022-12-21 | Details |
| L0488 | NCT06381076 | PHASE3 | RECRUITING | NO | 2025-02-03 | 2025-02-10 | Details |
| L0654 | NCT01668901 | PHASE4 | WITHDRAWN | NO | 2012-09 | 2016-10-25 | Details |
| L0664 | NCT02332811 | PHASE3 | COMPLETED | NO | 2013-10 | 2016-12-23 | Details |
| L0693 | NCT01439867 | PHASE2 | TERMINATED | YES | 2012-06-22 | 2020-06-17 | Details |
| L0719 | NCT06161766 | COMPLETED | NO | 2024-03-15 | 2024-12-09 | Details | |
| L0854 | NCT01209403 | PHASE4 | COMPLETED | NO | 2010-09 | 2011-09-30 | Details |
| L0870 | NCT05746559 | PHASE3 | RECRUITING | NO | 2023-04-06 | 2025-04-17 | Details |
| L1087 | NCT02827435 | RECRUITING | NO | 2016-07-01 | 2023-12-01 | Details | |
| L1258 | NCT01806610 | PHASE2 | WITHDRAWN | NO | 2013-08 | 2022-09-14 | Details |
| L1269 | NCT04256629 | PHASE1 | COMPLETED | YES | 2020-03-03 | 2022-01-31 | Details |
| L1485 | NCT03806530 | PHASE3 | COMPLETED | NO | 2019-05-01 | 2022-09-21 | Details |
| L1488 | NCT03380962 | PHASE1|PHASE2 | ACTIVE_NOT_RECRUITING | NO | 2018-02-27 | 2025-03-24 | Details |
| L1531 | NCT02243306 | PHASE1 | COMPLETED | YES | 2014-10-24 | 2019-04-09 | Details |
| L1607 | NCT00576602 | PHASE4 | TERMINATED | NO | 2007-12 | 2016-11-04 | Details |
| L1676 | NCT00211068 | COMPLETED | NO | 2004-03 | 2013-04-30 | Details | |
| L1773 | NCT00675220 | COMPLETED | NO | 2007-06 | 2016-10-28 | Details | |
| L2059 | NCT00673231 | PHASE3 | COMPLETED | YES | 2008-04 | 2013-10-29 | Details |
| L2154 | NCT01868594 | PHASE4 | COMPLETED | YES | 2013-05-07 | 2019-05-30 | Details |
| L2531 | NCT00286429 | PHASE3 | COMPLETED | YES | 2006-02 | 2012-02-03 | Details |
| L2560 | NCT00504712 | PHASE4 | COMPLETED | YES | 2006-02 | 2022-06-08 | Details |
| L2768 | NCT00506662 | PHASE4 | TERMINATED | YES | 2007-07 | 2023-08-14 | Details |
| L2928 | NCT00252772 | PHASE3 | TERMINATED | NO | 2004-09 | 2009-04-22 | Details |
| L3150 | NCT02173457 | PHASE3 | COMPLETED | NO | 2014-09 | 2019-10-25 | Details |
| L3399 | NCT05310916 | PHASE3 | UNKNOWN | NO | 2022-06-06 | 2022-06-10 | Details |
| L3408 | NCT02822534 | PHASE1 | UNKNOWN | NO | 2016-04 | 2016-07-04 | Details |
| L3409 | NCT02414958 | PHASE3 | COMPLETED | YES | 2015-06-30 | 2019-01-03 | Details |
| L3599 | NCT00513201 | PHASE4 | COMPLETED | NO | 2007-08-08 | Details | |
| L3828 | NCT02026310 | COMPLETED | NO | 2014-01 | 2016-01-28 | Details | |
| L3902 | NCT02545738 | PHASE4 | COMPLETED | NO | 2015-04 | 2016-08-10 | Details |
| L3922 | NCT00612950 | COMPLETED | NO | 2006-10 | 2008-02-12 | Details | |
| L4245 | NCT00481117 | PHASE1 | COMPLETED | NO | 2008-08 | 2010-09-13 | Details |
| L4422 | NCT06455319 | PHASE2 | NOT_YET_RECRUITING | NO | 2025-04 | 2024-10-18 | Details |
| L4452 | NCT00447213 | PHASE2|PHASE3 | COMPLETED | NO | 2007-04 | 2010-10-13 | Details |
| L4468 | NCT04180813 | TERMINATED | NO | 2020-03-04 | 2022-06-23 | Details | |
| L4598 | NCT02119819 | PHASE2 | COMPLETED | YES | 2014-04 | 2021-05-27 | Details |
| L4689 | NCT02725502 | UNKNOWN | NO | 2013-07 | 2016-04-01 | Details | |
| L4758 | NCT02470403 | PHASE2 | COMPLETED | YES | 2015-06-05 | 2021-01-05 | Details |
| L4805 | NCT01393808 | PHASE2 | COMPLETED | NO | 2011-09 | 2017-03-03 | Details |
| L4921 | NCT00905255 | PHASE3 | COMPLETED | YES | 2009-05 | 2016-12-21 | Details |
| L5004 | NCT01165684 | PHASE4 | COMPLETED | YES | 2010-10 | 2017-02-17 | Details |
| L5015 | NCT06789302 | PHASE2 | NOT_YET_RECRUITING | NO | 2025-06 | 2025-01-23 | Details |
| L5034 | NCT00653302 | PHASE4 | COMPLETED | NO | 2003-04 | 2008-12-03 | Details |
| L5048 | NCT00801164 | PHASE1 | COMPLETED | NO | 2008-12 | 2012-02-02 | Details |
| L5079 | NCT05747664 | PHASE1 | RECRUITING | NO | 2023-04-13 | 2024-04-08 | Details |
| L5080 | NCT00615264 | PHASE3 | COMPLETED | YES | 2005-09 | 2016-06-06 | Details |
| L5114 | NCT05084079 | PHASE4 | UNKNOWN | NO | 2021-11 | 2021-10-19 | Details |
| L5186 | NCT00366379 | PHASE2 | COMPLETED | NO | 2006-07 | 2016-11-02 | Details |
| L5232 | NCT01588743 | UNKNOWN | NO | 2008-10 | 2012-05-01 | Details | |
| L5357 | NCT01290575 | PHASE1 | COMPLETED | NO | 2011-02 | 2012-03-27 | Details |
| L5405 | NCT01915849 | PHASE1|PHASE2 | COMPLETED | YES | 2013-07 | 2015-02-06 | Details |
| L5519 | NCT04801199 | PHASE3 | COMPLETED | NO | 2020-01-26 | 2021-08-17 | Details |
| L5629 | NCT00495885 | PHASE3 | COMPLETED | NO | 2007-06 | 2016-05-26 | Details |
| L5676 | NCT01044537 | PHASE1 | COMPLETED | YES | 2010-02 | 2017-03-10 | Details |
| L5711 | NCT01536600 | COMPLETED | NO | 2004-09 | 2017-01-06 | Details | |
| L5736 | NCT02800252 | UNKNOWN | NO | 2016-06 | 2016-11-23 | Details | |
| L5840 | NCT00508287 | PHASE1 | COMPLETED | NO | 2007-08 | 2009-03-16 | Details |
| L5869 | NCT06220773 | PHASE3 | RECRUITING | NO | 2024-05-21 | 2024-05-22 | Details |
| L5882 | NCT00681460 | COMPLETED | NO | 2008-05 | 2015-05-27 | Details | |
| L5973 | NCT01441232 | PHASE1 | COMPLETED | NO | 2011-10 | 2012-01-31 | Details |
| L6038 | NCT00918138 | PHASE3 | COMPLETED | YES | 2009-08 | 2015-05-21 | Details |
| L6045 | NCT04457050 | PHASE4 | COMPLETED | NO | 2017-10-30 | 2020-07-07 | Details |
| L6095 | NCT00846716 | UNKNOWN | NO | 2008-03 | 2009-02-19 | Details | |
| L6132 | NCT01144975 | PHASE2 | COMPLETED | NO | 2010-05 | 2012-05-16 | Details |
| L6156 | NCT01811485 | PHASE3 | COMPLETED | YES | 2013-05 | 2015-02-23 | Details |
| L6224 | NCT02025907 | PHASE4 | COMPLETED | YES | 2014-02 | 2016-10-31 | Details |
| L6261 | NCT00374907 | PHASE3 | COMPLETED | YES | 2006-09 | 2015-05-07 | Details |
| L6327 | NCT00553488 | PHASE2 | COMPLETED | NO | 2007-09 | 2008-08-22 | Details |
| L6330 | NCT01381887 | PHASE1 | COMPLETED | NO | 2011-06 | 2013-04-22 | Details |
| L6362 | NCT05305287 | PHASE4 | RECRUITING | NO | 2022-11-01 | 2024-08-30 | Details |
| L6366 | NCT01366287 | PHASE1 | COMPLETED | NO | 2011-01 | 2011-06-06 | Details |
| L6396 | NCT05577728 | COMPLETED | NO | 2021-07-01 | 2024-09-25 | Details | |
| L6435 | NCT01316861 | PHASE3 | COMPLETED | NO | 2012-09 | 2013-09-25 | Details |
| L6463 | NCT00240383 | PHASE2|PHASE3 | COMPLETED | NO | 2002-05 | 2010-09-14 | Details |
| L6520 | NCT00885378 | PHASE3 | COMPLETED | YES | 2009-05 | 2015-06-01 | Details |
| L6527 | NCT00817778 | PHASE2 | COMPLETED | YES | 2009-01 | 2012-11-16 | Details |
| L6610 | NCT02771093 | PHASE4 | COMPLETED | YES | 2016-09-08 | 2023-12-12 | Details |
| L6623 | NCT06557811 | PHASE4 | NOT_YET_RECRUITING | NO | 2024-09-01 | 2024-08-26 | Details |
| L6629 | NCT02453711 | PHASE2 | COMPLETED | YES | 2015-10-01 | 2020-04-17 | Details |
| L6732 | NCT03707171 | PHASE3 | COMPLETED | NO | 2018-10-01 | 2019-07-10 | Details |
| L6799 | NCT02908087 | PHASE2 | COMPLETED | NO | 2016-03 | 2022-01-11 | Details |
| L6850 | NCT03848793 | PHASE2 | COMPLETED | NO | 2019-03-06 | 2022-11-07 | Details |
| L6864 | NCT01881828 | PHASE3 | COMPLETED | YES | 2013-09 | 2020-03-03 | Details |
| L6886 | NCT03815305 | PHASE4 | UNKNOWN | NO | 2018-07-30 | 2019-01-24 | Details |
| L7021 | NCT05759897 | PHASE2 | UNKNOWN | NO | 2023-02-28 | 2023-03-08 | Details |
| L7050 | NCT01707147 | COMPLETED | YES | 2012-11-16 | 2019-01-11 | Details | |
| L7057 | NCT03761797 | COMPLETED | YES | 2019-01-15 | 2023-01-23 | Details | |
| L7132 | NCT05624853 | PHASE4 | COMPLETED | NO | 2020-05-12 | 2023-10-23 | Details |
| L7148 | NCT03596177 | PHASE2 | COMPLETED | YES | 2018-09-26 | 2023-01-19 | Details |
| L7168 | NCT01676233 | PHASE1 | COMPLETED | NO | 2012-09 | 2013-08-19 | Details |
| L7245 | NCT02882477 | PHASE2|PHASE3 | UNKNOWN | NO | 2016-12 | 2016-08-29 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|