Investigational Drug Details
| Drug ID: | D481 |
| Drug Name: | Bisacodyl |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB09020 |
| DrugBank Description: | Bisacodyl is an organic stimulant laxative that acts directly on the colon to promote bowel movement. Bisacodyl is prescribed for constipation, neurogenic bowel dysfunction, and bowel preparation before medical examinations. |
| PubChem ID: | 2391 |
| CasNo: | 603-50-9 |
| Repositioning for NAFLD: | Yes |
| SMILES: | CC(=O)OC1=CC=C(C=C1)C(C1=CC=C(OC(C)=O)C=C1)C1=CC=CC=N1 |
| Structure: |
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| InChiKey: | KHOITXIGCFIULA-UHFFFAOYSA-N |
| Molecular Weight: | 361.3906 |
| DrugBank Targets: | Aquaporin-3; NA |
| DrugBank MoA: | Induces diarrhea which cleanses the colon. |
| DrugBank Pharmacology: | Bisacodyl is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis. |
| DrugBank Indication: | Indicated for cleansing of the colon as a preparation for colonoscopy in adults. |
| Targets: | |
| Therapeutic Category: | |
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