Investigational Drug Details
| Drug ID: | D496 |
| Drug Name: | Methyl salicylate |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB09543 |
| DrugBank Description: | Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments. It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. It is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions. |
| PubChem ID: | 4133 |
| CasNo: | 119-36-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | COC(=O)C1=CC=CC=C1O |
| Structure: |
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| InChiKey: | OSWPMRLSEDHDFF-UHFFFAOYSA-N |
| Molecular Weight: | 152.1473 |
| DrugBank Targets: | |
| DrugBank MoA: | Counter-irritation is thought to be effective at alleviating musculoskeletal pain as the irritation of the sensory nerve endings is thought to alter or offset pain in the underlying muscle or joints that are served by the same nerves [A19285]. This is thought to mask the underlying musculoskeletal pain and discomfort. When applied topically, methyl salicylate is thought to penetrate the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2. |
| DrugBank Pharmacology: | Methyl salicylate relieve musculoskeletal pain in the muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. It is pharmacologically similar to aspirin and other NSAIDs but as a topical agent it primarily acts as a rubefacient and skin irritant. Counter-irritation is believed to cause a soothing sensation of warmth. |
| DrugBank Indication: | Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine. |
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