Investigational Drug Details
| Drug ID: | D497 |
| Drug Name: | Ixazomib |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB09570 |
| DrugBank Description: | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration. |
| PubChem ID: | 25183872 |
| CasNo: | 1072833-77-2 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [H][C@@](CC(C)C)(N=C(O)CN=C(O)C1=C(Cl)C=CC(Cl)=C1)B(O)O |
| Structure: |
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| InChiKey: | MXAYKZJJDUDWDS-LBPRGKRZSA-N |
| Molecular Weight: | 361.03 |
| DrugBank Targets: | |
| DrugBank MoA: | Ixazomib is an N-capped dipeptidyl leucine boronic acid which reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic β1 and β2 subunits and to induce accumulation of ubiquitinated proteins. |
| DrugBank Pharmacology: | In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies. In mouse xenograft models, ixazomib induced tumor growth inhibition. |
| DrugBank Indication: | Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L3003 | NCT01029886 | PHASE3 | COMPLETED | YES | 2010-01 | 2015-04-09 | Details |
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