Investigational Drug Details
| Drug ID: | D009 |
| Drug Name: | L-Lysine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00123 |
| DrugBank Description: | L-Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. L-Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell. |
| PubChem ID: | 5962 |
| CasNo: | 56-87-1 |
| Repositioning for NAFLD: | Yes |
| SMILES: | NCCCC[C@H](N)C(O)=O |
| Structure: |
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| InChiKey: | KDXKERNSBIXSRK-YFKPBYRVSA-N |
| Molecular Weight: | 146.1876 |
| DrugBank Targets: | High affinity cationic amino acid transporter 1; Cationic amino acid transporter 4; Cationic amino acid transporter 3; Low affinity cationic amino acid transporter 2; Lysine--tRNA ligase |
| DrugBank MoA: | Proteins of the herpes simplex virus are rich in L-arginine, and tissue culture studies indicate an enhancing effect on viral replication when the amino acid ratio of L-arginine to L-lysine is high in the tissue culture media. When the ratio of L-lysine to L-arginine is high, viral replication and the cytopathogenicity of herpes simplex virus have been found to be inhibited. L-lysine may facilitate the absorption of calcium from the small intestine. |
| DrugBank Pharmacology: | Insures the adequate absorption of calcium; helps form collagen ( which makes up bone cartilage & connective tissues); aids in the production of antibodies, hormones & enzymes. Recent studies have shown that Lysine may be effective against herpes by improving the balance of nutrients that reduce viral growth. A deficiency may result in tiredness, inability to concentrate, irritability, bloodshot eyes, retarded growth, hair loss, anemia & reproductive problems. |
| DrugBank Indication: | Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L5202 | NCT04655690 | PHASE1 | COMPLETED | NO | 2020-11-09 | 2023-01-03 | Details |
| L7375 | NCT06560333 | PHASE3 | NOT_YET_RECRUITING | NO | 2026-11-30 | 2024-08-21 | Details |
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