In vitro & In vivo Models
In vitro & in vivo models of CKD are manually extracted from research articles.
157 records.
| Model ID | Category | Class | Type | Model | Description | Source | Reference (PMIDs) |
|---|---|---|---|---|---|---|---|
| M041 | In vitro | Cell line | Cell line | EJM | EJM | Homo sapiens | |
| M042 | In vitro | Tissue model | Epididymis | Epididymis | Concentration that causes 50% inhibition of mammalian alpha-mannosidase was determined in rat epididymis | Rattus norvegicus | 7966130 |
| M043 | In vitro | Cell line | Cell line | Fibroblast | Fibroblasts (Fibroblast cells) | Homo sapiens | 32146376 |
| M044 | In vitro | Cell line | Cell line | GEO | Inhibition of IR phosphorylation in human GEO cells | Homo sapiens | 24900240 |
| M045 | In vitro | Cell line | Cell line | GeneBLAzer PPARgamma-UAS-bla HEK 293H | Agonist activity at PPAR gamma in GeneBLAzer PPARgamma-UAS-bla HEK 293H cells preincubated with compound for 16 to 24 hrs followed by substrate addition and measured after 2 hrs by fluorescence plate reader analysis | Homo sapiens | 37702400 |
| M046 | In vitro | Cell line | Cell line | HCA7 | Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by luciferase reporter assay | Homo sapiens | 18665581 |
| M047 | In vitro | Cell line | Tumor-derived cell line | HCT-116 | HCT-116 (Colon carcinoma cells) | Homo sapiens | 22480433 |
| M048 | In vitro | Cell line | Cell line | HEK | Displacement of 2-[125I]iodoMLT from human MT2 receptor stably expressed in HEK cells incubated for 120 mins | Homo sapiens | 36150258 |
| M049 | In vitro | Cell line | Cell line | HEK-293T | HEK-293T (A derivative of HEK-293 cells containing the SV40 T-antigen) | Homo sapiens | 11472221 |
| M050 | In vitro | Cell line | Cell line | HEK293 | HEK293 (Embryonic kidney fibroblasts) | Homo sapiens | 11063602 |
| M051 | In vitro | Cell line | Cell line | HEK293-A | HEK293-A | Homo sapiens | 23137448 |
| M052 | In vitro | Cell line | Cell line | HEK293-H | Inhibition of wild-type full-length human sphingosine 1-phosphate lyase transfected in HEK293-H cells preincubated for 30 mins followed by addition of NBD-sphingosine for 3 hrs by fluorescence analysis | Homo sapiens | 27020302 |
| M053 | In vitro | Cell line | Cell line | HEK293-MSRII | Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Homo sapiens | 23886683 |
| M054 | In vitro | Cell line | Cell line | HEK293-T-REx | Inhibition of APOL1 G1 variant in human HEK293-T-REx cells measured by Thallium assay | Homo sapiens | |
| M055 | In vitro | Cell line | Cell line | HEK293E | Agonist activity at Gal4DBD-fused human PPAR-gamma LBD transfected in HEK293E cells co-transfected with Peak12-Gal4UAS-luci assessed as receptor transactivation at 10 uM incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 36375336 |
| M056 | In vitro | Cell line | Cell line | HEK293F | Inhibition of human TRPC6 expressed in HEK293F cells assessed as inhibition of carbachol-induced calcium response up to 20 uM | Homo sapiens | 33749283 |
| M057 | In vitro | Cell line | Cell line | HEK293T | Agonist activity at PPARgamma (unknown origin) expressed in HEK293T cells at 10 uM incubated for 14 to 16 hrs under irradiation by hybrid Gal4 reporter gene assay | Homo sapiens | 27726356 |
| M058 | In vitro | Cell line | Cell line | HFF | HFF (Foreskin fibroblasts) | Homo sapiens | |
| M059 | In vitro | Cell line | Cell line | HG5LN | Activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in HG5LN cells after 18 hrs by luciferase reporter gene assay | Homo sapiens | 27815118 |
| M060 | In vitro | Cell line | Cell line | HL-60 | HL-60 (Promyeloblast leukemia cells) | Homo sapiens | 21292481 |