Therapeutic Strategy Details
| Strategy ID: | S02 |
| Strategy: | anti-fibrosis |
| Other Terms: | Anti-fibrosis; Anti-hypertensive; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-fibrosis; Anti-inflammatory; Anti-fibrosis; anti-fibrosis; Anti-inflammatory; Anti-oxidative stress; Anti-fibrosis; Anti-fibrosis; Enhance lipid metabolism; Enhance lipid metabolism; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; Improve insulin resistance; Enhance lipid metabolism; Regulating intestinal flora; Anti-fibrosis; Anti-fibrosis; Anti-inflammatory; Anti-apoptosis; Anti-hypertensive; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-fibrosis; Anti-fibrosis; Enhance lipid metabolism; Improve insulin resistance; Anti-inflammatory; Anti-fibrosis; Enhance lipid metabolism; Anti-fibrosis; Anti-inflammatory; Anti-oxidative stress; Anti-fibrosis; Anti-apoptosis; Cell therapy; Anti-inflammatory; Anti-fibrosis; Anti-inflammatory; Anti-fibrosis; Anti-apoptosis; Cell therapy; Anti-fibrosis; Improve insulin resistance; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; Anti-fibrosis; Anti-inflammatory; Anti-hypertensive; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; Anti-apoptosis; Anti-fibrosis; Anti-inflammatory; Anti-oxidative stress; Anti-fibrosis; Anti-apoptosis; Enhance lipid metabolism; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-inflammatory; Anti-oxidative stress; Anti-lipogenesis; Anti-fibrosis |
| Related Targets: | HIF; FGF23; MAPK; Nrf2; HO-1; p38 MAPK; JNK; PPAR; FXR; Smad2/3; Smad2/3; TLR4; Smad2/3; Wnt/β-catenin; Smad2/3; Smad4; TGF-β; IL-1β; IL-6; TNF-α; ACE; Smad4; PKD1; p62; mTOR; TNF-α; TLR4; TGF-β; erythropoietin receptor; MMP-9; TLR4; IL-2; IL-24; IL-2; NOX4; MAPK; ACE; NF-κB; STAT3; JAK2; NOX4; NF-κB; Nrf2; SGLT2; HIF; Smad2/3; NF-κB; AMPK; mTOR; ERK; MAPK; AMPK; IL-6; IL-1β; TNF-α; TGF-β; EGF; RAGE; Wnt/β-catenin; AKT; AMPK; NOX4; caspase-3; NLRP3; NLRP3; NF-κB; Smad2/3; Smad2/3; p38 MAPK; p53 |
| Related Drugs: | riociguat; sGC stimulators; sGC activators; MRI-1867; JD5037; 1400W; HIF-PH inhibitors; paricalcitol; LNA-anti-miR-150; scrambled LNA; Ganoderic acid; GA-A; BML-111; ML385; traditional medicine; saikosaponin B2; miR-9-5p; cisplatin; CP; obeticholic acid (OCA; 6-ethyl chenodeoxycholic acid); tropifexor; nidufexor; mdivi-1; silibinin; lisinopril; MK-521; Adriamycin; 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione; NOX5 siRNA; ICG-001; IC-2; IC-2-506-1; IC-2-506-2; IC-2-506-3; IC-2-Ar-Cl; IC-2-OH; IC-2-OTBS; IC-2-F; Rehmannia glutinosa leaves total glycoside; glucose; glucosamine; streptozotocin; Low molecular weight fucoidan; protamine sulfate; propionate; Hirudin; Hsub2/subS; NO; Hsub2/subSxa0; xa0; NO; angiotensin-converting enzyme inhibitors; angiotensin II receptor blockers; N-acetyl-seryl-aspartyl-lysyl-proline; USC; Korean red ginseng; Panax ginseng C.A. Mey.; streptozotocin; dapagliflozin; losartan; Bisphosphonates; RIS; recombinant human soluble thrombomodulin; deacetylase inhibitors; Human recombinant erythropoietin; rEPO; Huangkui capsule; 1,25sub2/subDsub3/sub; Danggui-Shaoyao-San; IL-24; Jiawei Shuilu Erxiandan; Coptis; CH5451098; MRS1754; Retinoic acid; ACE inhibitors; ATsub1/sub receptor antagonists; N-acetyl-seryl-aspartyl-lysyl-proline; glycolysis inhibitors; prolyl oligopeptidase inhibitor S17092; imidapril; TA-606; Baicalin; β-Caryophyllene; dapagliflozin; streptozocin; fosinopril; valsartan; Chrysophanol; Plantamajoside; miR-101a-3p; miR-101; Am80; all-trans retinoic acid; Ginsenoside Rb1; rapamycin; Akt inhibitor; metformin; p38-MAPK inhibitor; ERK-MAPK inhibitor; psoralen; GLP-1RAs; liraglutide; XAV-939; streptozocin; TGF-x3b2; 1; dencichine; streptozotocin; genistein; Streptozotocin; transforming growth factor-x3b2; 1; paramylon; streptozotocin; C-peptide; SKF96365; TRPC6-siRNA; NFAT2-siRNA; ICG-001; short-chain fatty acids; acetate; propionate; butyrate; GPR43 agonist; TRAIL; PF429242; liraglutide; enalapril; canagliflozin; isoprenaline; Liuwei Dihuang pill; streptozotocin; six novel poricoic acids from Poria cocos; poricoic acid ZM; poricoic acid ZP; secolanostane tetracyclic triterpenoids; emodin; HGF; traditional Chinese medicine; Western medicine therapies; Sauchinone; Shenkang VII recipe; rhEPO; MOCK-MPs; hEPO-MPs; Calcium dobesilate; topiroxostat; siXDH; Ginkgo biloba extract; Streptozotocin; recombinant thrombomodulin |
| Mechanism: | |
| Reference (PMIDs): | 30689085; 31454063; 31630548; 31740151; 31787235; 31804606; 31881376; 31901891; 31914684; 31914692; 31940200; 31949126; 31953678; 31965641; 31972423; 32012145; 32012313; 32028239; 32039769; 32054986; 32057847; 32061840; 32066115; 32068124; 32085655; 32096161; 32112899; 32116017; 32140785; 32146474; 32182705; 32184703; 32192327; 32240615; 32297575; 32306980; 32310009; 32324796; 32340145; 32348995; 32352559; 32360619; 32416450; 32444604; 32466632; 32511988; 32605460; 32633566; 32651445; 32659400; 32698907; 32715762; 32720699; 32721462; 32739204; 32746936; 32747424; 32764782; 32798559; 32798711; 32800850; 32819586; 32831998; 32857135; 32865015; 32877912; 32887916; 32914833; 32920287; 32943844; 32957343; 32977573; 32980902; 32993806; 33011612; 33050202; 33068650; 33069430 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
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| Article ID | PMID | Source | Title |
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