Therapeutic Strategy Details
| Strategy ID: | S05 |
| Strategy: | anti-oxidative stress |
| Other Terms: | Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-inflammatory; Anti-oxidative stress; Enhance lipid metabolism; Improve insulin resistance; Anti-oxidative stress; Anti-oxidative stress; Anti-oxidative stress; Anti-inflammatory; Anti-apoptosis; Anti-inflammatory; Anti-oxidative stress; Anti-fibrosis; Anti-apoptosis; Anti-oxidative stress; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; anti-inflammatory; anti-oxidative stress; Anti-oxidative stress; Anti-inflammatory; Anti-inflammatory; Anti-oxidative stress; Anti-apoptosis; Anti-oxidative stress; Anti-fibrosis; Enhance lipid metabolism; Anti-oxidative stress; Anti-inflammatory; Anti-oxidative stress; Anti-fibrosis; Anti-apoptosis; Anti-oxidative stress (Epigallocatechin-3-gallate (EGCG) activates Nrf2/ARE signaling pathway by downregulating Keap1 and boosting nuclear Nrf2 level); Anti-hypertensive; Anti-oxidative stress; Improve insulin resistance; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-inflammatory; Anti-fibrosis; Anti-apoptosis; Anti-oxidative stress; Anti-apoptosis; Anti-fibrosis; Anti-inflammatory; Anti-oxidative stress; relieving oxidative stress; Enhance lipid metabolism; Anti-inflammatory; Anti-fibrosis; Anti-oxidative stress; Anti-inflammatory; Anti-oxidative stress; Anti-lipogenesis; Anti-fibrosis |
| Related Targets: | TNF-α; NF-κB; MAPK; caspase-3; Bcl-2; DPP4; Nrf2; HO-1; p38 MAPK; JNK; SGLT2; mineralocorticoid receptor; MMP-9; AMPK; HIF; HIF; Smad2/3; Smad2/3; VEGFA; IL-6; MAPK; IL-1β; EGFR; Wnt/β-catenin; HO-1; NF-κB; NOX4; MAPK; NF-κB; STAT3; JAK2; NOX4; NF-κB; Nrf2; NF-κB; NOX4; SIRT1; AMPK; Nrf2; AMPK; NOX4; caspase-3; ERK; JNK; p38 MAPK; NLRP3; NLRP3; NF-κB; AMPK; AMPK; Bcl-2; Nrf2; Smad2/3; NOX4 |
| Related Drugs: | MRI-1867; JD5037; 1400W; Glatiramer acetate; Glatiramer; Berberine; GKT137831; febuxostat; topiroxostat; Oleuropein; Resveratrol; Dipeptidyl peptidase-4 inhibitors; alogliptin; saxagliptin; sitagliptin; teneligliptin; phenolic-rich açaí seed extract; BML-111; ML385; empagliflozin; dapagliflozin; ramipril; hydro-chloro-thiazide; iN/i-acetylcysteine; aminoguanidine; metformin; l-cysteine; NOX5 siRNA; gentamicin; syringic acid; streptozotocin; tamarind seed coat ethanol extract; Finerenone; USC; probiotics; Lactobacillus; Bifidobacterium; Sodium-glucose cotransporter 2 inhibitors; SGLT2 inhibitors; Cyanidin-3-glucoside; N-acetylcysteine; quercetin; formononetin; calycosin; 7-O-methylisomucronulatol; quercetin; streptozotocin; Astragaloside IV; Akebia saponin D; Retinoic acid; Folic acid; N-acetyl-cysteine; Baicalin; β-Caryophyllene; Ergosterol; Streptozotocin; GKT137831; GKT13783; Sodium-glucose cotransporter 2 inhibitors; Plantamajoside; Capsicum annuum L.; dencichine; reactive oxygen species scavenger; Ang II receptor blockers; Epigallocatechin-3-gallate; type 1 angiotensin II receptor blockade; olmesartan; short-chain fatty acids; acetate; propionate; butyrate; GPR43 agonist; Tiliacora triandra extract; 5,7-dihydroxy-6-oxoheptadecanoic acid; canagliflozin; isoprenaline; streptozotocin; recombinant human clusterin protein; six novel poricoic acids from Poria cocos; poricoic acid ZM; poricoic acid ZP; secolanostane tetracyclic triterpenoids; Chloroquine; Amodiaquine; Streptozotocin; Allopurinol; febuxostat; Terminalia bellerica; Epicatechin; 2,3-dihydroxybenzoic acid; 3,4-dihydroxyphenylacetic acid; 3-hydroxyphenylpropionic acid; Sauchinone; GLP-1; liraglutide; exendin-4; Cinacalcet; mitoquinone; ML385; sodium nitrite; isoquercetin; vitamin E; selenium; SIS3; Forskolin; topiroxostat; siXDH; Ginkgo biloba extract; Streptozotocin; puromycin aminonucleoside; amiloride |
| Mechanism: | |
| Reference (PMIDs): | 31454063; 31697931; 31734944; 31740428; 31748427; 31755322; 31786186; 31876965; 31881376; 31936266; 31963523; 32012145; 32015680; 32072913; 32079523; 32088716; 32096161; 32124701; 32164457; 32192334; 32203558; 32215271; 32323727; 32339782; 32344355; 32348995; 32360615; 32360619; 32416450; 32446112; 32493401; 32534886; 32605460; 32670409; 32721462; 32722241; 32756181; 32768570; 32786093; 32831998; 32875596; 32887916; 32913257; 32920287; 32924342; 32933504; 32959859; 32977573; 32985256; 32999168; 33011276; 33023894; 33039650; 33046439; 33050202; 33068650; 33070369 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
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| Article ID | PMID | Source | Title |
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