Therapeutic Target Details
| Target ID: | T07 |
| Target Name: | Potassium channel, inwardly rectifying, subfamily J, member 11 |
| Synonyms: | ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11 |
| GENE: | KCNJ11 |
| Action: | OPENER |
| Class: | Target is a single protein chain |
| UniProtKB ID: | Q14654 |
| Entry Name: | KCNJ11_HUMAN |
| Related Drugs: | Diazoxide |
| Mechanism: | Potassium channel, inwardly rectifying, subfamily J, member 11 opener |
| Reference (PMIDs): |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B021997 | CHEMBL18861 | Small molecule | ZD-6169 | 337.3 | C17H14F3NO3 | NEUTRAL | Details |
| B073056 | CHEMBL48174 | Small molecule | 462.78 | C20H13ClF6N2O2 | NEUTRAL | Details | |
| B073057 | CHEMBL48890 | Small molecule | 470.84 | C20H21ClF6N2O2 | NEUTRAL | Details | |
| B073278 | CHEMBL50501 | Small molecule | 430.14 | C15H10BrF6NO2 | NEUTRAL | Details | |
| B073279 | CHEMBL49701 | Small molecule | 367.25 | C15H11F6NO3 | NEUTRAL | Details | |
| B073280 | CHEMBL49321 | Small molecule | 367.25 | C15H11F6NO3 | NEUTRAL | Details | |
| B073434 | CHEMBL300969 | Small molecule | 391.31 | C18H15F6NO2 | NEUTRAL | Details | |
| B073465 | CHEMBL45749 | Small molecule | 381.27 | C16H13F6NO3 | NEUTRAL | Details | |
| B073466 | CHEMBL45937 | Small molecule | 419.37 | C20H19F6NO2 | NEUTRAL | Details | |
| B073477 | CHEMBL50760 | Small molecule | 365.27 | C16H13F6NO2 | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|