Therapeutic Target Details
| Target ID: | T09 |
| Target Name: | Serine/threonine-protein kinase AKT2 |
| Synonyms: | RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; RAC protein kinase beta; PKB beta; RAC-PK-beta; 2.7.11.1 |
| GENE: | AKT2 |
| Action: | INHIBITOR |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P31751 |
| Entry Name: | AKT2_HUMAN |
| Related Drugs: | Bay-1125976 |
| Mechanism: | Serine/threonine-protein kinase AKT2 inhibitor |
| Reference (PMIDs): |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000250 | CHEMBL10 | Small molecule | SB-203580 | 377.44 | C21H16FN3OS | NEUTRAL | Details |
| B000273 | CHEMBL440084 | Small molecule | SB-431542 | 384.4 | C22H16N4O3 | NEUTRAL | Details |
| B000923 | CHEMBL413 | Small molecule | SIROLIMUS | 914.19 | C51H79NO13 | NEUTRAL | Details |
| B012922 | CHEMBL274654 | Small molecule | ORANTINIB | 310.35 | C18H18N2O3 | ACID | Details |
| B013048 | CHEMBL535 | Small molecule | SUNITINIB | 398.48 | C22H27FN4O2 | BASE | Details |
| B013629 | CHEMBL274064 | Small molecule | SB-220025 | 338.39 | C18H19FN6 | BASE | Details |
| B014221 | CHEMBL14762 | Small molecule | SELICICLIB | 354.46 | C19H26N6O | NEUTRAL | Details |
| B014264 | CHEMBL14249 | Small molecule | ADENOSINE TRIPHOSPHATE | 507.18 | C10H16N5O13P3 | ACID | Details |
| B014366 | CHEMBL428690 | Small molecule | ALVOCIDIB | 401.85 | C21H20ClNO5 | NEUTRAL | Details |
| B014785 | CHEMBL553 | Small molecule | ERLOTINIB | 393.44 | C22H23N3O4 | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|