| Outcome Measures: |
Primary: Measured Glomerular Filtration Rate (GFR), GFR will be measured by the iohexol plasma clearance technique, Changes from baseline to the end of one-month treatment period and one-month recovery period | Secondary: 24 hour urinary output, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary protein excretion, mean of the measurement in three consecutive 24-hour urine collection, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary albumin excretion, mean of the measurement in three consecutive 24-hour urine collection, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary urea excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary phosphate excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary sodium excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary glucose excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary potassium excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary uric acid excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour urinary creatinine excretion, last of three consecutive collections, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of total protein calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of albumin calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of sodium calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of potassium calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of uric acid calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Fractional clearance of free water calculated by standard formulas, Changes from baseline to the end of one-month treatment period and one-month recovery period|Glucose disposal rate, Performed by hyperinsulinemic euglycemic clamp and by standard oral glucose load and HOMA index;, Changes from baseline to the end of one-month treatment period and one-month recovery period|Glucose tolerance, Performed by hyperinsulinemic euglycemic clamp and by standard oral glucose load and HOMA index;, Changes from baseline to the end of one-month treatment period and one-month recovery period|Office blood pressure, Changes from baseline to the end of one-month treatment period and one-month recovery period|Office heart rate, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour (day-time and night-time) blood pressure monitoring, Changes from baseline to the end of one-month treatment period and one-month recovery period|24 hour (day-time and night-time) heart rate monitoring, Changes from baseline to the end of one-month treatment period and one-month recovery period|Pulse wave velocity, These parameters will be measured by tonometry, Changes from baseline to the end of one-month treatment period and one-month recovery period|other marker of vascular stiffness, These parameters will be measured by tonometry, Changes from baseline to the end of one-month treatment period and one-month recovery period|Indices of Quality of Life: questionnaire SF-36, By submission of validate questionnaire, Changes from baseline to the end of one-month treatment period and one-month recovery period
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