| Outcome Measures: |
Primary: Firibastat and metabolites Concentrations, The plasma concentration data for firibastat (QGC001), EC33 and QGC515, will be analysed at each time measurement (predose, 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 24, 36, 48 hours post-dose), Day 1 to Day 3 | Secondary: Systolic and Diastolic Blood Pressure (mmHg), Systolic and Diastolic blood pressure, Day 1 to Day 3|Heart Rate (bpm), number of beats per minute, Day 1 to Day 3|Hematology blood sample laboratory tests aggregated as number of patients outside ranges, Hemoglobin, Hematocrit, MCH, MCHC, MCV, MPV, RBC (erythrocytes), WBC (Leucocytes), Differential Count (Basophils, Eosinophils, Lymphocytes, Monocytes, Neutrophils, Large Unstained cells), Platelets., Day 1 to Day 3|Biochemistry blood sample laboratory tests aggregated as number of patients outside ranges, Albumin, Alkaline Phosphatase, ALT, Amylase, AST, Bicarbonate, Bilirubin (direct, indirect and total), Calcium, Chloride, Cholesterol, Creatinine Kinase, Creatinine, gammaGT, HDLcholesterol, LDH, LDL - cholesterol, Lipase, Magnesium, Phosphate, Potassium, Protein total, Sodium, Triglycerides, Urea, Uric Acid, Glucose., Day 1 to Day 3|Hemostasis blood sample laboratory tests aggregated as number of patients outside ranges, INR, PT, aPTT, Day 1 to Day 3|Urinalysis tests aggregated as number of patients outside ranges, pH, ketone bodies, proteins, glucose, occult blood, blood leukocytes, nitrite, bilirubin, urobilinogen, density., Day 1 to Day 3
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