| Outcome Measures: |
Primary: Change in estimated glomerular filtration rate(eGFR), Blood samples will be collected for analysis of glomerular filtration rate(eGFR) every 2weeks ., 12 weeks|Change in urinary microalbumin/creatinine ratio(uACR), Urine samples will be collected for analysis of urinary microalbumin/creatinine ratio(uACR) every 2weeks., 12 weeks|Concentration of N terminal pro B type natriuretic peptide(NT-prpBNP), Blood samples will be collected for analysis of concentration of N terminal pro B type natriuretic peptide(NT-proBNP) every 2weeks., 12 weeks | Secondary: blood uric acid, Blood samples will be collected for analysis of uric acid every 2weeks., 12 weeks|Rate of HbA1c, Blood samples will be collected for analysis of HbA1c every 2weeks., 12weeks|Systolic and diastolic blood pressure, Systolic and diastolic blood pressure will be measured every 2weeks., 12 weeks|left ventricle eject fraction, Cardiac ultrasound will be measured every 2weeks., 12 weeks|Concentration of postassium, Blood samples will be collected for analysis of concentration of postassium every 2weeks., 12 weeks|Concentration of serum troponin, Blood samples will be collected for analysis of concentration of serum troponin every 2weeks., 12 weeks|Concentration of alanine aminotransferase or aspartate aminotransferase, Blood samples will be collected for analysis of concentration of alanine aminotransferase or aspartate aminotransferase every 2weeks., 12 weeks|Concentration of sodio, Urine samples will be collected for analysis of concentration of sodion every 2weeks., 12 weeks
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