| Outcome Measures: |
Primary: Change from Baseline in Glomerular Filtration Rate (mGFR), The GFR in milliliter/minute per1.73 square meter (mL/min/1.73 m²) using iohexol clearance (mGFR-measured glomerular filtration rate), Baseline, Week 24 | Secondary: Change from Baseline in Urine Albumin-to-Creatinine Ratio (UACR), Baseline, Week 24|Change from Baseline in Creatinine-Corrected Fractional Urinary Sodium Excretion (FENa), Baseline, Week 24|Change from Baseline in Filtration Fraction Estimated from Measured Glomerular Filtration Rate (mGFR), Baseline, Week 24|Change from Baseline in Renal Mean Arterial Flow as Assessed by Magnetic Resonance Imaging (MRI), Corrected by Hematocrit, Baseline, Week 24|Change from Baseline in in Mean Arterial Flow (MAF), Baseline, Week 24|Change from Baseline in Renal Artery Resistive Index (RARI), Baseline, Week 24|Change from Baseline in Renal Blood Flow Velocity Peak Systolic Velocity (PSV) and End-diastolic Velocity (ESV), Baseline, Week 24|Change from Baseline in Global Renal Perfusion (MRI), Baseline, Week 24|Change from Baseline in Total Renal Parenchyma Volume (MRI), Baseline, Week 24|Change from Baseline in Renal Cortex Volume (MRI), Baseline, Week 24|Change from Baseline in Renal Cortex T1 (ms) (MRI), Baseline, Week 24|Change from Baseline in Medulla T1 (ms) (MRI), Baseline, Week 24|Change from Baseline in Renal Cortex R2 (BOLD MRI), Baseline, Week 24|Change from Baseline in Medulla R2, Baseline, Week 24|Change from Baseline in Body Weight, Baseline, Week 24|Change from Baseline in 24-hr Urinary Albumin Excretion (UAE), Baseline, Week 24|Change from Baseline in Change in 24-hour (hr) Urinary Electrolytes (milligrams/24hr (mg/24h)), Baseline, Week 24
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| Locations: |
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona, 85225, United States|Care Access - 801 South Power Road, Mesa, Mesa, Arizona, 85206, United States|Headlands Research - Scottsdale, Scottsdale, Arizona, 85260, United States|Medical Advancement Centers of Arizona, Tempe, Arizona, 85283, United States|Hope Clinical Research, Inc., Canoga Park, California, 91303, United States|Catalina Research Institute, LLC, Montclair, California, 91763, United States|Peninsula Research Associates, Rolling Hills Estates, California, 90274, United States|University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, United States|Teradan Clinical Trials, LLC, Brandon, Florida, 33511, United States|Suncoast Clinical Research, Inc., New Port Richey, Florida, 34652, United States|Great Lakes Clinical Trials - Ravenswood, Chicago, Illinois, 60640, United States|Indiana University Health University Hospital, Indianapolis, Indiana, 46202, United States|Prime Health and Wellness/SKYCRNG, Fayette, Mississippi, 39069, United States|Palm Research Center Tenaya, Las Vegas, Nevada, 89128, United States|NYU Langone Hospital - Long Island, Mineola, New York, 11501, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Victorium Clinical Research - Houston, Houston, Texas, 77024, United States|Endocrine Ips, Pllc, Houston, Texas, 77079, United States|Tranquility Research, Webster, Texas, 77598, United States|Centricity Research Brampton Endocrinology, Brampton, Ontario, L6S 0C6, Canada|Circulate Cardiac & Vascular Centre, Burlington, Ontario, L7M 1K9, Canada|North York Diagnostic and Cardiac Centre, North York, Ontario, M6B 3H7, Canada|Stouffville Medical Research Institute Inc., Stouffville, Ontario, L4A 1H2, Canada|Dr. Anil K. Gupta Medicine Professional Corporation, Toronto, Ontario, M9V 4B4, Canada|Fadia El Boreky Medicine, Waterloo, Ontario, N2J 1C4, Canada|Viacar Recherche Clinique, Greenfield Park, Quebec, J4V 2G8, Canada|Diex Recherche Joliette, Joliette, Quebec, J6E 6A9, Canada|9109-0126 Quebec Inc., Montreal, Quebec, H4N 2W2, Canada|Centro Cardiologico Monzino, Milan, Milano, 20138, Italy|Azienda Ospedaliera Universitaria Pisana, Pisa, Toscana, 56126, Italy|Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, 24127, Italy|Ospedale San Raffaele, Milano, 20132, Italy|Hospital Clinico de Valencia, Valencia, Valenciana, Comunitat, 46010, Spain|Hospital Universitario Doctor Peset, Valencia, Valenciana, Comunitat, 46017, Spain|Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE), Sevilla, 41003, Spain|Addenbrooke's Hospital, Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom|FutureMeds Teesside - Middlefield Centre, Stockton-on-Tees, Durham County, TS19 8PE, United Kingdom|Royal London Hospital, London, England, E1 1BB, United Kingdom|Futuremeds-Newcastle, Newcastle, England, United Kingdom|Vascular Research Team, Salford, Greater Manchester, M6 8HD, United Kingdom|North Middlesex Hospital, London, London, City Of, N18 1QX, United Kingdom|City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, NG5 1PB, United Kingdom
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