| Outcome Measures: |
Primary: Change From Baseline to Endpoint MMTT AUC(0-4h) for Plasma Glucose, MMTT=Mixed Meal Tolerance Test AUC=Area Under Curve, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint MMTT C_max for Plasma Glucose, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(1-2h) for Plasma C-Peptide, GGI=Glucose and GLP1 infusion AUC=Area Under Curve, Day -1 to Day 3 and Day 6 to Day 9 | Secondary: Change From Baseline to Endpoint MMTT AUC(0-4h) for Plasma Insulin, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline MMTT AUC(0-4h) for Plasma Glucagon, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint MMTT AUC(0-4h) for Plasma C-Peptide, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(0-1h) for Plasma Insulin, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(1-2h) for Plasma Insulin, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(0-1h) for Plasma Glucagon, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(1-2h) for Plasma Glucagon, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint Fasting Beta-cell Responsiveness, Day -1 to Day 3 and Day 6 to Day 9|Fasting Insulin at Endpoint, Day 3 and Day 9|Maximum Plasma AZD1981 Concentration at Steady-State, C_ss,Max, Days 2,3,8,9|Time of Maximum Plasma AZD1081 Concentration, t_ss,Max, Days 2,3,8,9|Plasma AZD1981 AUC(0-1h), Days 2,3,8,9|Plasma AZD1981 AUC(0-2h), Days 2,3,8,9|Minimum Plasma AZD1981 Concentration at Steady-State, C_ss,Min, Days 2,3,8,9|Plasma AZD1981 AUC(1-2h), Days 2,3,8,9|Plasma Paracetamol Maximum Concentration, C_max, Days 3,9|Time of Maximum Plasma Paracetamol Concentration, t_max, Days 3,9|Plasma Paracetamol AUC(0-t), Days 3,9|Change From Baseline to Endpoint GGI AUC(0-1h) for Plasma C-Peptide, Day -1 to Day 3 and Day 6 to Day 9|Change From Baseline to Endpoint GGI AUC(0-24h) for Plasma Glucose, Day -1 to Day 3 and Day 6 to Day 9|Plasma AZD1981 AUC(0-4h), Days 2,3,8,9|Plasma AZD1981 AUC(0-12h), Days 2,3,8,9|Plasma AZD1981 AUC(0-24h), Days 2,3,8,9|Apparent Oral Plasma AZD1981 at Steady-State, CL_ss/F, Days 2,3,8,9
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