| Outcome Measures: |
Primary: Differences in lactulose mannitol ratio (LMR) test as a measure of intestinal permeability between treatment groups, The ratio of lactulose to mannitol will be measured in urine collected within 6 hours after ingestion of dual sugar. This ratio predominantly reflects small intestine permeability., Week 16 (visit 6) | Secondary: Differences between treatment groups in plasma LBP, Marker of intestinal permeability, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in Serum zonulin, Marker of intestinal permeability, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in Fecal Calprotectin, Marker of intestinal inflammation, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in plasma IL-6, Marker of chronic inflammation, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in plasma IL-8, Marker of chronic inflammation, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in plasma TNFα, Marker of chronic inflammation, Week 8 (visit 4), Week 16 (visit 6)|Differences between treatment groups in plasma hs-CRP, Marker of chronic inflammation, Week 8 (visit 4), Week 16 (visit 6) | Other: Exploratory: determine the effect of semaglutide as compared to placebo on intestinal microbiota in relation to changes in intestinal permeability and inflammatory markers, Microbiome study, Visit 6 (week 16)
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