| Outcome Measures: |
Primary: Change from Baseline in fasting plasma Low Density Lipoprotein cholesterol, Week 24 or Final Visit | Secondary: Change from Baseline in Triglycerides, Week 24 or Final Visit|Change from Baseline in Total Cholesterol, Week 24 or Final Visit|Change from Baseline in High Density Lipoprotein cholesterol, Week 24 or Final Visit|Change from Baseline in Very Low Density Lipoprotein cholesterol, Week 24 or Final Visit|Change from Baseline in apolipoprotein A1, Week 24 or Final Visit|Change from Baseline in apolipoprotein B, Week 24 or Final Visit|Change from Baseline in non- High Density Lipoprotein cholesterol, Week 24 or Final Visit|Change from Baseline in the ratio of Low Density Lipoprotein cholesterol/High Density Lipoprotein cholesterol, Week 24 or Final Visit|Change from Baseline in the ratio of Total Cholesterol/High Density Lipoprotein cholesterol, Week 24 or Final Visit|Change from Baseline in the ratio of apolipoprotein A1/apolipoprotein B, Week 24 or Final Visit|Change from Baseline in high-sensitivity C-reactive protein, Week 24 or Final Visit|Percentage of subjects who achieve Low Density Lipoprotein cholesterol concentrations less than 1.81 mmol/L (70 mg/dL), Week 24 or Final Visit|Percentage of subjects who achieve Low Density Lipoprotein cholesterol concentrations less than 2.59 mmol/L (100 mg/dL), Week 24 or Final Visit|Percentage of subjects who achieve Low Density Lipoprotein cholesterol concentrations less than 3.37 mmol/L (130 mg/dL), Week 24 or Final Visit|Best corrected visual acuity, Week 24 or Final Visit|Adverse Events, Weeks 2, 4, 8, 12, 16, 20, and 24 or Final Visit|Clinical Laboratory Tests, Weeks 2, 4, 8, 12, 16, 20, and 24 or Final Visit|Vital Signs, Weeks 2, 4, 8, 12, 16, 20, and 24 or Final Visit|12-lead Electrocardiogram, Weeks 12 and 24 or Final Visit|Physical Examination, Week 24 or Final Visit
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| Locations: |
Tucson, Arizona, United States|Artesia, California, United States|Jacksonville, Florida, United States|Dunwoody, Georgia, United States|Idaho Falls, Idaho, United States|Aurora, Illinois, United States|Chicago, Illinois, United States|Melrose Park, Illinois, United States|Naperville, Illinois, United States|Overland Park, Kansas, United States|Livonia, Michigan, United States|Chesterfield, Missouri, United States|Margate, New Jersey, United States|Trenton, New Jersey, United States|Cincinnati, Ohio, United States|Bristol, Tennessee, United States|San Antonio, Texas, United States|Richmond, Virginia, United States|Benesov, Czech Republic|Holice v Cechach, Czech Republic|Kladno, Czech Republic|Mlada Boleslav, Czech Republic|Olomouc, Czech Republic|Praha, Czech Republic|Trutnov, Czech Republic|Usti nad Orlici, Czech Republic|Zlin, Czech Republic|Parnu, Estonia|Tallinn, Estonia|Tartu, Estonia|Helsinki, Finland|Hyvinkaa, Finland|Tampere, Finland|Turku, Finland|Berlin, Germany|Bochum, Germany|Chemnitz, Germany|Dresden, Germany|Frankfurt, Germany|Goerlitz, Germany|Leipzig, Germany|Nurnberg, Germany|Krakow, Poland|Leszno, Poland|Lublin, Poland|Niemodlin, Poland|Ostrowiec Swietokrzyski, Poland|Skierniewice, Poland|Sroda Wlkp, Poland|Starachowice, Poland|Warszawa, Poland|Zakopane, Poland|Banska Bystrica, Slovakia|Bojnice, Slovakia|Bratislava, Slovakia|Lucenec, Slovakia|Presov, Slovakia|Samorin, Slovakia|Zilina, Slovakia|Bloemfontein, South Africa|Cape Town, South Africa|Durban, South Africa|Lyttleton, South Africa|Pretoria, South Africa|Randburg, South Africa|Bath, United Kingdom|Birmingham, United Kingdom|Blackpool, United Kingdom|Blantyre, United Kingdom|Chippenham, United Kingdom|Edinburgh, United Kingdom|Glasgow, United Kingdom|Harrow, United Kingdom|Hinckley, United Kingdom|Newport, United Kingdom|NOttingham, United Kingdom|Woolpit, United Kingdom
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