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Clinical Trial Details

Trial ID: L0200
Source ID: NCT01100203
Associated Drug: Eplerenone
Title: Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function
Acronym: ALBLOCK-2
Status: TERMINATED
Study Results: NO
Results:
Conditions: Chronic Kidney Disease
Interventions: DRUG: Eplerenone
Outcome Measures: Primary: Pulse wave velocity, Pulse wave velocity measured using the SphygmoCor device., 24 weeks|Pulse Wave velocity, 12 weeks|Pulse wave velocity, baseline | Secondary: Ambulatory arterial stiffness index, 24 hour ambulatory blood pressure measurements, give rise to the index, which is a secondary measure of arterial compliance., 24 weeks|Pulse wave analysis, Parameters are Augmentation Index, subendocardial viability ratio, pulse, time to reflection, ejection duration., 24 weeks|Albuminuria, Will be calculated from 24 hour urine collections., baseline|Pulse wave analysis, baseline|Ambulatory arterial stiffness index, baseline|Ambulatory arterial stiffness index, 12 weeks|Pulse wave analysis, 12 weeks|Albuminuria, 12 weeks|Albuminuria, 24 weeks|Estimated glomerular filtration rate (eGFR), Estimated glomerular filtration rate (eGFR) will be calculated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula., baseline|Estimated glomerular filtration rate (eGFR), 12 weeks|Estimated glomerular filtration rate (eGFR), 24 weeks|Plasma potassium, baseline|Plasma potassium, week 1|Plasma potassium, week 2|Plasma potassium, week 4|Plasma potassium, week 8|Plasma potassium, week 12|Plasma potassium, week 16|plasma potassium, week 20|plasma potassium, week 24|Blood pressure, BP will be measured at all visits, baseline|Blood pressure, 12 weeks|Blood pressure, 24 weeks
Sponsor/Collaborators: Sponsor: Lene Boesby | Collaborators: Rigshospitalet, Denmark
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 54
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2010-04
Completion Date: 2012-02
Results First Posted:
Last Update Posted: 2012-02-08
Locations: Dept. Nephrology, Herlev Hospital, Herlev, DK-2730, Denmark|Herlev Hospital, Herlev, DK-2730, Denmark
URL: https://clinicaltrials.gov/show/NCT01100203