| Trial ID: | L2036 |
| Source ID: | NCT05008276
|
| Associated Drug: |
Aminohippurate Sodium Inj 20%
|
| Title: |
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
|
| Acronym: |
|
| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes Mellitus|Diabetic Kidney Disease|Adolescent Obesity|Pre Diabetes|Kidney Hypoxia|Puberty
|
| Interventions: |
DRUG: Aminohippurate Sodium Inj 20%|DRUG: Iohexol Inj 300 MG/ML|DRUG: Dextran 40
|
| Outcome Measures: |
Primary: Effective renal plasma flow (ERPF), Measured by PAH Clearance, 3 Hours|Glomerular Filtration Rate (GFR), Measured by iohexol clearance, 3 hours | Secondary: Insulin Sensitivity, Measured by IV glucose tolerance test (IVGTT), 3 hours|Renal perfusion, Arterial spin labeling (ASL) MRI, 10 min|Renal oxygenation, Blood oxygen level dependent (BOLD) MRI, 60 min
|
| Sponsor/Collaborators: |
Sponsor: Petter Bjornstad | Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Seattle Children's Hospital|University of Colorado, Denver
|
| Gender: |
ALL
|
| Age: |
CHILD
|
| Phases: |
|
| Enrollment: |
100
|
| Study Type: |
OBSERVATIONAL
|
| Study Designs: |
Observational Model: |Time Perspective: p
|
| Start Date: |
2021-09-27
|
| Completion Date: |
2027-12-01
|
| Results First Posted: |
|
| Last Update Posted: |
2025-03-24
|
| Locations: |
Children's Hospital Colorado, Aurora, Colorado, 80045, United States|Seattle Children's Hospital, Seattle, Washington, 98102, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT05008276
|
