| Trial ID: | L0229 |
| Source ID: | NCT00586261
|
| Associated Drug: |
Pioglitazone
|
| Title: |
Does Thiazolidinedione Therapy Improve Endothelial Function and Preserve Renal Function
|
| Acronym: |
|
| Status: |
TERMINATED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT00586261/results
|
| Conditions: |
Chronic Kidney Disease
|
| Interventions: |
DRUG: Pioglitazone|DRUG: Placebo|DRUG: Nitroglycerin
|
| Outcome Measures: |
Primary: Change in Brachial Arterial Reactivity, Brachial arterial reactivity was measured by ultrasound. A blood pressure cuff was placed around the right forearm. Using the ultrasound probe of the ultrasound, 2-dimensional images clearly defining the anterior and posterior intimal wall of the brachial artery were collected. Flow velocities were then measured using pulsed wave Doppler. The blood pressure cuff previously placed around the patient's right forearm was inflated to 200 mmHg. The cuff remained inflated for 5 minutes as the patient remained motionless and quiet. Prior to deflation, the patient was asked to remain still as flow velocities and 2-dimensional images were obtained immediately following cuff deflation. Then a 0.4 mg sublingual nitroglycerin tablet was given to all patients without a contraindication and all measurements were repeated., After 6 months of treatment |
|
| Sponsor/Collaborators: |
Sponsor: Mayo Clinic
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
36
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2006-03
|
| Completion Date: |
2009-07
|
| Results First Posted: |
2013-03-07
|
| Last Update Posted: |
2013-03-15
|
| Locations: |
Mayo Clinic, Rochester, Minnesota, 55905, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT00586261
|
