CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Clinical Trial Details

Trial ID:	L2319
Source ID:	NCT00318422
Associated Drug:	Liraglutide
Title:	Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
Acronym:	LEAD-1
Status:	COMPLETED
Study Results:	NO
Results:
Conditions:	Diabetes\|Diabetes Mellitus, Type 2
Interventions:	DRUG: liraglutide\|DRUG: rosiglitazone\|DRUG: glimepiride
Outcome Measures:	Primary: HbA1c, after 26 weeks of treatment \| Secondary: body weight\|Safety and tolerability\|beta-cell function\|Glycemic control parameters (fasting plasma glucose, -glucose profiles)
Sponsor/Collaborators:	Sponsor: Novo Nordisk A/S
Gender:	ALL
Age:	ADULT, OLDER_ADULT
Phases:	PHASE3
Enrollment:	1041
Study Type:	INTERVENTIONAL
Study Designs:	Allocation: RANDOMIZED\|Intervention Model: PARALLEL\|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)\|Primary Purpose: TREATMENT
Start Date:	2006-05
Completion Date:	2007-05
Results First Posted:
Last Update Posted:	2017-01-25
Locations:	Novo Nordisk Investigational Site, Buenos Aires, B1636DSU, Argentina\|Novo Nordisk Investigational Site, Buenos Aires, C1181ACH, Argentina\|Novo Nordisk Investigational Site, Buenos Aires, C1425AGC, Argentina\|Novo Nordisk Investigational Site, Córdoba, 5000, Argentina\|Novo Nordisk Investigational Site, Mar del Plata, B7602CBM, Argentina\|Novo Nordisk Investigational Site, Mendoza, 5500, Argentina\|Novo Nordisk Investigational Site, Woolloongabba, Queensland, 4102, Australia\|Novo Nordisk Investigational Site, Melbourne, Victoria, 3004, Australia\|Novo Nordisk Investigational Site, Caboolture, 4510, Australia\|Novo Nordisk Investigational Site, Ingleburn, 2565, Australia\|Novo Nordisk Investigational Site, Kippa Ring, 4021, Australia\|Novo Nordisk Investigational Site, Miranda, 2228, Australia\|Novo Nordisk Investigational Site, Randwick, 2031, Australia\|Novo Nordisk Investigational Site, Southport, 4215, Australia\|Novo Nordisk Investigational Site, Stones Corner, 4120, Australia\|Novo Nordisk Investigational Site, Fortaleza, 60120-021, Brazil\|Novo Nordisk Investigational Site, Sao Paulo, 04022-001, Brazil\|Novo Nordisk Investigational Site, Pleven, 5800, Bulgaria\|Novo Nordisk Investigational Site, Plovdiv, 4002, Bulgaria\|Novo Nordisk Investigational Site, Russe, 7000, Bulgaria\|Novo Nordisk Investigational Site, Sofia, 1431, Bulgaria\|Novo Nordisk Investigational Site, Sofia, 1606, Bulgaria\|Novo Nordisk Investigational Site, Varna, 9010, Bulgaria\|Novo Nordisk Investigational Site, Osijek, 31 000, Croatia\|Novo Nordisk Investigational Site, Slavonski Brod, 35 000, Croatia\|Novo Nordisk Investigational Site, Split, 21 000, Croatia\|Novo Nordisk Investigational Site, Brno, 65691, Czech Republic\|Novo Nordisk Investigational Site, Hradec Králové, 500 36, Czech Republic\|Novo Nordisk Investigational Site, Ostrava, 70852, Czech Republic\|Novo Nordisk Investigational Site, Plzen - Lochotin, 30460, Czech Republic\|Novo Nordisk Investigational Site, Prague 4, 140 21, Czech Republic\|Novo Nordisk Investigational Site, Praha 10, 10034, Czech Republic\|Novo Nordisk Investigational Site, Praha 5, 15018, Czech Republic\|Novo Nordisk Investigational Site, Espoo, 02740, Finland\|Novo Nordisk Investigational Site, Helsinki, 00150, Finland\|Novo Nordisk Investigational Site, Lahti, 15110, Finland\|Novo Nordisk Investigational Site, Nurmijärvi, 01900, Finland\|Novo Nordisk Investigational Site, Oulu, FI-90100, Finland\|Novo Nordisk Investigational Site, Pieksämäki, 76100, Finland\|Novo Nordisk Investigational Site, Rauma, 26100, Finland\|Novo Nordisk Investigational Site, Rovaniemi, 96100, Finland\|Novo Nordisk Investigational Site, Tampere, 33100, Finland\|Novo Nordisk Investigational Site, Tampere, 33101, Finland\|Novo Nordisk Investigational Site, DAX, 40107, France\|Novo Nordisk Investigational Site, LA ROCHELLE cedex, 17019, France\|Novo Nordisk Investigational Site, Montpellier, 34295, France\|Novo Nordisk Investigational Site, Mougins, 06250, France\|Novo Nordisk Investigational Site, Narbonne, 11108, France\|Novo Nordisk Investigational Site, NEVERS cedex, 58033, France\|Novo Nordisk Investigational Site, Paris, 75877, France\|Novo Nordisk Investigational Site, Rennes, 35056, France\|Novo Nordisk Investigational Site, Saint Mandé, 94160, France\|Novo Nordisk Investigational Site, Athens, 115 21, Greece\|Novo Nordisk Investigational Site, Athens, 151 23, Greece\|Novo Nordisk Investigational Site, Athens, GR-10552, Greece\|Novo Nordisk Investigational Site, Athens, GR-11527, Greece\|Novo Nordisk Investigational Site, Mumbai, Maharashtra, 4000021, India\|Novo Nordisk Investigational Site, Chandigarh, Punjab, 160012, India\|Novo Nordisk Investigational Site, Chennai, 600116, India\|Novo Nordisk Investigational Site, Mumbai, 400 0067, India\|Novo Nordisk Investigational Site, Haifa, 31096, Israel\|Novo Nordisk Investigational Site, Jerusalem, 91120, Israel\|Novo Nordisk Investigational Site, Tel Hashomer, 52621, Israel\|Novo Nordisk Investigational Site, Catania, 95122, Italy\|Novo Nordisk Investigational Site, Lucca, 55100, Italy\|Novo Nordisk Investigational Site, Milano, 20132, Italy\|Novo Nordisk Investigational Site, Napoli, 80138, Italy\|Novo Nordisk Investigational Site, Perugia, 06126, Italy\|Novo Nordisk Investigational Site, Ravenna, 48121, Italy\|Novo Nordisk Investigational Site, Roma, 00189, Italy\|Novo Nordisk Investigational Site, Torino, 10144, Italy\|Novo Nordisk Investigational Site, Seoul, 08308, Korea, Republic of\|Novo Nordisk Investigational Site, Seoul, 130-701, Korea, Republic of\|Novo Nordisk Investigational Site, Seoul, 137-701, Korea, Republic of\|Novo Nordisk Investigational Site, Cheras, 56000, Malaysia\|Novo Nordisk Investigational Site, Kota Bharu, Kelantan, 16150, Malaysia\|Novo Nordisk Investigational Site, Pulau Pinang, 10990, Malaysia\|Novo Nordisk Investigational Site, Davao City, 8000, Philippines\|Novo Nordisk Investigational Site, Makati City, 1218, Philippines\|Novo Nordisk Investigational Site, Marikina City, 1100, Philippines\|Novo Nordisk Investigational Site, Quezon City, 1100, Philippines\|Novo Nordisk Investigational Site, Bytom, 41-902, Poland\|Novo Nordisk Investigational Site, Gdansk, 80-858, Poland\|Novo Nordisk Investigational Site, Gniewkowo, 88-140, Poland\|Novo Nordisk Investigational Site, Kamieniec Zabkowicki, 57-230, Poland\|Novo Nordisk Investigational Site, Krakow, 31-455, Poland\|Novo Nordisk Investigational Site, Lodz, 90-030, Poland\|Novo Nordisk Investigational Site, Lublin, 20-081, Poland\|Novo Nordisk Investigational Site, Lublin, 20-538, Poland\|Novo Nordisk Investigational Site, Mazowieckie, 09-400, Poland\|Novo Nordisk Investigational Site, Nysa, 48-300, Poland\|Novo Nordisk Investigational Site, Rawa Mazowiecka, 96-200, Poland\|Novo Nordisk Investigational Site, Szczecin, 71-455, Poland\|Novo Nordisk Investigational Site, Tychy, 43-100, Poland\|Novo Nordisk Investigational Site, Warszawa, 01-911, Poland\|Novo Nordisk Investigational Site, Zabrze, 41-800, Poland\|Novo Nordisk Investigational Site, Ploiesti, Prahova, 100097, Romania\|Novo Nordisk Investigational Site, Baia Mare, 430032, Romania\|Novo Nordisk Investigational Site, Brasov, 500269, Romania\|Novo Nordisk Investigational Site, Bucharest, 020475, Romania\|Novo Nordisk Investigational Site, Timisoara, 300736, Romania\|Novo Nordisk Investigational Site, Johannesburg, Gauteng, 1829, South Africa\|Novo Nordisk Investigational Site, Johannesburg, Gauteng, 2001, South Africa\|Novo Nordisk Investigational Site, Johannesburg, Gauteng, 2076, South Africa\|Novo Nordisk Investigational Site, Durban, KwaZulu-Natal, 4001, South Africa\|Novo Nordisk Investigational Site, Umhlanga, 4320, South Africa\|Novo Nordisk Investigational Site, Gijón, 33206, Spain\|Novo Nordisk Investigational Site, Palma de Mallorca, 07198, Spain\|Novo Nordisk Investigational Site, Reus, 43201, Spain\|Novo Nordisk Investigational Site, Bern, 3010, Switzerland\|Novo Nordisk Investigational Site, Lausanne, 1011, Switzerland\|Novo Nordisk Investigational Site, St. Gallen, 9007, Switzerland\|Novo Nordisk Investigational Site, Zürich, 8032, Switzerland\|Novo Nordisk Investigational Site, Zürich, 8091, Switzerland\|Novo Nordisk Investigational Site, Changhua, 500, Taiwan\|Novo Nordisk Investigational Site, Kaohsiung City, 833, Taiwan\|Novo Nordisk Investigational Site, Taipei, 100, Taiwan\|Novo Nordisk Investigational Site, Taipei, 231, Taiwan\|Novo Nordisk Investigational Site, Bangkok, 10110, Thailand\|Novo Nordisk Investigational Site, Bangkok, 10330, Thailand\|Novo Nordisk Investigational Site, Bangkok, 10400, Thailand\|Novo Nordisk Investigational Site, Ankara, 06500, Turkey\|Novo Nordisk Investigational Site, Antalya, 07059, Turkey\|Novo Nordisk Investigational Site, Istanbul, 34390, Turkey\|Novo Nordisk Investigational Site, Istanbul, 34718, Turkey\|Novo Nordisk Investigational Site, Istanbul, 34890, Turkey\|Novo Nordisk Investigational Site, Izmir, 35340, Turkey
URL:	https://clinicaltrials.gov/show/NCT00318422

Knowledge Graph
Associated Data

Drug ID	Drug Name	Type	DrugBank ID	Targets	Category	Latest Progress
D116	Rosiglitazone	small molecule	DB00412				Details

Clinical Trial Details

Summary

Knowledge Graph

Associated Data

Associated NAFLD Drugs (1)