| Outcome Measures: |
Primary: Time to first occurrence of composite endpoint of new-onset diabetes and major cardiovascular events., composite endpoint includes new-onset diabetes, cardiovascular death, ischemic stroke, myocardial infarction, angina with evidence of ischemia, and arterial revascularization, 3 years | Secondary: Time to new-onset diabetes, Diabetes is determined by oral glucose tolerance test, clinical diagnosis or use of glucose-lowering medications., 3 years|Normalization of glucose parameters, Meeting all three criteria: 1) Fasting plasma glucose (FPG)\<6.1 mmol/L; 2) 2-hour postprandial blood glucose (2hPG)\<7.8 mmol/L; 3) HbA1c\<5.7%., 3 years|Time to first occurrence of composite endpoint of major cardiovascular event 1, cardiovascular death, ischemic stroke, myocardial infarction, angina with evidence of ischemia, and arterial revascularization, 3 years|Time to first occurrence of composite endpoint of major cardiovascular event 2, cardiovascular death, ischemic stroke and myocardial infarction, 3 years|Time to all-cause death, Death due to all causes, 3 years|Time to newly diagnosed cancer, all events of cancer or classified by primary sites, 3 years | Other: Change of depressive symptoms, Measured by Patient Health Questionnaire-9 (PHQ-9), 1 year|Time to the components of major cardiovascular events 1, Time to first occurrence of cardiovascular death, 3 years|Time to the components of major cardiovascular events 2, Time to first occurrence of fatal or non-fatal ischemic stroke, 3 years|Time to the components of major cardiovascular events 3, Time to first occurrence of fatal or non-fatal myocardial infarction, 3 years|Time to the components of major cardiovascular events 4, Time to first occurrence of angina with evidence of ischemia, 3 years|Time to the components of major cardiovascular events 5, Time to first occurrence of arterial revascularization (including coronary or non-coronary), 3 years|Subgroup analysis 1 for primary outcome measure, Age (\<65, ≥65), 3 years|Subgroup analysis 2 for primary outcome measure, Sex (male, female), 3 years|Subgroup analysis 3 for primary outcome measure, Body mass index (\<28kg/cm2, ≥28kg/cm2), 3 years|Subgroup analysis 4 for primary outcome measure, Type of prediabetes (isolated impaired fasting glucose \[6.1 mmol/L≤FPG\<7.0 mmol/L, 2hPG\<7.8 mmol/L\], isolated impaired glucose tolerance \[FPG\<6.1 mmol/L, 7.8mmol/L≤2hPG\<11.1 mmol/L\], impaired fasting glucose and impaired glucose tolerance \[6.1 mmol/L≤FPG\<7.0 mmol/L, 7.8mmol/L≤2hPG\<11.1 mmol/L\]), 3 years|Subgroup analysis 5 for primary outcome measure, hypertension (yes, no), 3 years|Subgroup analysis 6 for primary outcome measure, Current smoker (yes, no), 3 years|Subgroup analysis 7 for primary outcome measure, Triglyceride (\<1.7mmol/L, ≥1.7mmol/L), 3 years|Subgroup analysis 8 for primary outcome measure, HDL-C (\<1.0mmol/L, ≥1.0mmol/L), 3 years|Subgroup analysis 9 for primary outcome measure, LDL-C (≤3.4mmol/L, \>3.4mmol/L), 3 years|Subgroup analysis 10 for primary outcome measure, Family history of premature coronary heart disease (biological father's diagnosis of myocardial infarction, receipt of percutaneous coronary intervention, or coronary artery bypass grafting before 55 years-old, or biological mother's diagnosis of myocardial infarction, receipt of percutaneous coronary intervention, or coronary artery bypass grafting before 65 years-old), 3 years
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