| Outcome Measures: |
Primary: HbA1c, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Fasting plasma glucose, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week | Secondary: Fasting serum insulin, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Serum glucagon, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Serum glycoalbumin, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Serum leptin, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Serum adiponectin, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Body weight, 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Waist circumference, at 0, 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, and 52-week|Self-measured blood glucose, Subjects measure blood glucose 7 times a day on any 3 days in a week before each scheduled visit and record the results in the patient diary, at 0, 20, 52-week|Adverse events (AEs), vital signs, and laboratory tests, All treatment period
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