| Outcome Measures: |
Primary: Carotid intima-media thickness (CIMT), Progression (increase in mean CIMT in millimeters \[mm\]) or regression (reduction \> o = 0.020 mm on mean CIMT) after 2 years of follow-up, 24 months|Myocardial stiffness indexes, Change from baseline in: Left Ventricular Ejection Fraction (LVEF) in percentage (%), Diastolic Left Ventricular Dimension (LVDs) in centimeters (cm) Interventricular Septum thickness (IVS) in cm left vetricular posterior wall thickness (PWs) in cm, 24 months|Urinary albumin to creatinine ratio excretion, Development of microalbuminuria in normoalbuminuric patients at baseline or development of macroalbuminuria in patients with microalbuminuria at baseline; regression of microalbuminuria to normoalbuminuria or regression of macroalbuminuria to microalbuminuria, 24 months | Secondary: Weight, Change in body weight in kilograms (kg) from baseline, 24 months|Body mass index (BMI), Change in body mass index in Kg/mq from baseline, 24 months|Waist circumference (WC), Change in waist circumference in cm from baseline, 24 months|Blood pressure, Change in systolic and dyastolic blood pressure in mmHg from baseline, 24 months|estimated Glomerular filtration rate (eGFR), Change in estimated glomerular filtration rate in mI/min/1.73 mq from baseline, 24 months | Other: HbA1c, Change in HbA1c in % from baseline, 24 months|Mean amplitude glucose excursions (MAGE), Change in MAGE in mmol/L from baseline, 24 months|Lipid profile, Change in total cholesterol, tryglicerides, HDL-cholesterol, and LDL-cholesterol in mg/dL from baseline, 24 months
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