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Clinical Trial Details

Trial ID: L2440
Source ID: NCT00549757
Associated Drug: Aliskiren
Title: Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases)
Acronym: ALTITUDE
Status: TERMINATED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT00549757/results
Conditions: Type 2 Diabetes Mellitus|Cardiovascular Disease
Interventions: DRUG: Aliskiren|DRUG: Placebo
Outcome Measures: Primary: Percentage of Participants With Occurrence of Primary Composite Endpoint (Core : Active Treatment Phase), Occurrence was defined as the first event of the following composite primary endpoint: * Cardiovascular (CV) death * Resuscitated sudden death * Non-fatal myocardial infarction (MI) * Non-fatal stroke * Unplanned hospitalization for heart failure (HF) * Onset of end-stage renal disease (ESRD) or death due to renal failure. Onset of ESRD was defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 μmol/L), sustained for at least a month. * Doubling of baseline serum creatinine concentration, sustained for at least one month. To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory. The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., Time from randomization to the first event (Maximum 50 months)|Percentage of Participants With Cardiovascular (CV) Death (Core: Active Treatment Phase), Time from randomization to the first event (Maximum 50 months)|Percentage of Participants With Resuscitated Sudden Death (Core: Active Treatment Phase), Resuscitated sudden death was adjudicated when a subject experiences sudden death or cardiac arrest and is successfully resuscitated by cardioversion, defibrillation or cardiopulmonary resuscitation with a meaningful recovery of consciousness. This definition excludes known transient losses of consciousness such as seizure or vasovagal episodes that do not reflect significant cardiac dysfunction., Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With Fatal/Non-fatal Myocardial Infarction (MI) (Core: Active Treatment Phase), Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With Fatal/Non-fatal Stroke (Core: Active Treatment Phase), Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With Onset of End-stage Renal Disease (ESRD) (Core: Active Treatment Phase), ESRD is defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 µmol per liter) or renal death, Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With Doubling of Baseline Serum Creatinine Concentration, Sustained for at Least One Month (Core: Active Treatment Phase), To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory. The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With Unplanned Hospitalization for Heart Failure (Core: Active Treatment Phase), Time from randomization to the first event (Maximum 50 Months)|Percentage of Participants With All Cause Mortality (Core: Active Treatment Phase), Time from randomization to the first event (Maximum 50 months)|Percentage of Participants With Occurrence of Primary Composite Endpoint (Extension Phase), Occurrence was defined as the first event of the following composite primary endpoint: * Cardiovascular (CV) death * Resuscitated sudden death * Non-fatal myocardial infarction (MI) * Non-fatal stroke * Unplanned hospitalization for heart failure (HF) * Onset of end-stage renal disease (ESRD) or death due to renal failure. Onset of ESRD was defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 μmol/L), sustained for at least a month. * Doubling of baseline serum creatinine concentration, sustained for at least one month. To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory. The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With Cardiovascular (CV) Death (Extension Phase), from cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With Resuscitated Sudden Death (Extension Phase), From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants Fatal/Non-fatal Myocardial Infarction (MI) (Extension Phase), From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 month in average)|Percentage of Participants With Fatal/Non-fatal Stroke (Extension Phase), From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With Onset of End-stage Renal Disease (ESRD) (Extension Phase), ESRD is defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 µmol per liter) or renal death, From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants Doubling of Baseline Serum Creatinine Concentration, Sustained for at Least One Month (Extension Phase), To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory. The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With Unplanned Hospitalization for Heart Failure (Extension Phase), From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With All Cause Mortality (Extension Phase), from cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average) | Secondary: Percentage of Participants With Occurrence of Secondary Cardiovascular Composite Endpoint (Core: Active Treatment Phase), Occurrence was defined as the first event of the following secondary cardiovascular composite endpoint: * Cardiovascular (CV) death * Resuscitated sudden death * Non-fatal myocardial infarction (MI) * Non-fatal stroke * Unplanned hospitalization for heart failure (HF), Time from randomization to the first event (Maximum 50 months)|Percentage of Participants With Occurrence of Secondary Renal Composite Endpoint (Core: Active Treatment Phase), Occurrence was defined as the first event of the following secondary renal composite endpoint: * Onset of end-stage renal disease (ESRD) or death due to renal failure. Onset of ESRD was defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 μmol/L), sustained for at least a month. * Doubling of baseline serum creatinine concentration, sustained for at least one month. To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory.The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., Time from randomization to the first event (Maximum 50 months)|Percentage of Participants With Occurrence of Secondary Cardiovascular Composite Endpoint (Extension Phase), Occurrence was defined as the first event of the following secondary cardiovascular composite endpoint: * Cardiovascular (CV) death * Resuscitated sudden death * Non-fatal myocardial infarction (MI) * Non-fatal stroke * Unplanned hospitalization for heart failure (HF), From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)|Percentage of Participants With Occurrence of Secondary Renal Composite Endpoint (Extension Phase), Occurrence was defined as the first event of the following secondary renal composite endpoint: * Onset of end-stage renal disease (ESRD) or death due to renal failure. Onset of ESRD was defined as initiation of dialysis, renal transplantation, or a serum creatinine concentration above 6.0 mg/dL (530 μmol/L), sustained for at least a month. * Doubling of baseline serum creatinine concentration, sustained for at least one month. To fulfill the endpoint, the serum creatinine concentration had to be above the upper limit of normal for men and women according to the central laboratory. The upper limit of normal for men is 1.20 mg/dL and for women is 0.91 mg/dL., From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average) | Other: Percentage of Participants With Angioedema/Angioedema-like or Colorectal Events (Core : Active Treatment Phase), AEs of special interest were reported according to a post-marketing commitment to Health Authorities and included angioedema/angioedema-like events and colorectal events/ procedures, Time from randomization to the first event (Maximum 50 months)|Change From Baseline in Urinary Albumin to Creatinine Ratio (UACR) to Month 6 and to Last Measurement (Core : Active Treatment Phase), Baseline is the geometric mean of last 3 measurements before visit 3, Post-baseline value is the geometric mean of last 3 measurements during each visit. Change from Baseline = Post - Baseline., Baseline, Month 6 , last measurement (maximum at 50 months)|Mean Changes in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Month 3 and Month 6 (Core : Active Treatment Phase), The eGFR calculation was based on the Abbreviated Modification of Diet in Renal Disease (MDRD) Study Equation. Using this method, the applicable MDRD formula to calculate eGFR was as follows: Estimated GFR (mL/min/1.73 m\^2) = 175 x (serum creatinine in mg/dL) -1.154 x (Age in years) -0.203 x (0.742 if female) x (1.210 if Black) Mean changes in eGFR from baseline to month 3 and month 6 were included for analysis. The LS Mean and Standard Error were based on an ANCOVA repeated-measure model with treatment, visit, treatment-by-visit and baseline eGFR as effect terms., Baseline to Month 3 and Month 6|Percentage of Participants With Angioedema/Angioedema-like Events or Colorectal Events (Extension Phase), AEs of special interest were reported according to a post-marketing commitment to Health Authorities and included angioedema/angioedema-like events and colorectal events/ procedures., From cut-off date (20Dec2011/End of Treatment (EOT) ) to the first event after cut-off date (9 months in average)
Sponsor/Collaborators: Sponsor: Novartis Pharmaceuticals
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 8606
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2007-10
Completion Date: 2013-02
Results First Posted: 2014-03-18
Last Update Posted: 2014-04-21
Locations: Novartis Investigative Site, Birmingham, Alabama, 35209, United States|Novartis Investigative Site, Birmingham, Alabama, 35235, United States|Novartis Investigative Site, Huntsville, Alabama, 35801, United States|Novartis Investigative Site, Mobile, Alabama, 36608, United States|Novartis Investigative Site, Mobile, Alabama, 36617, United States|Novartis Investigative Site, Montgomery, Alabama, 36106, United States|Novartis Investigative Site, Muscle Shoals, Alabama, 35662, United States|Novartis Investigative Site, Peoria, Arizona, 85381, United States|Novartis Investigative Site, Phoenix, Arizona, 85032, United States|Novartis Investigative Site, Tucson, Arizona, 85712, United States|Novartis Investigative Site, Tucson, Arizona, 85741, United States|Novartis Investigative Site, Fayetteville, Arkansas, 72703, United States|Novartis Investigative Site, Burlingame, California, 94010, United States|Novartis Investigative Site, Fullerton, California, 92835, United States|Novartis Investigative Site, Huntington Beach, California, 92648, United States|Novartis Investigative Site, Oakland, California, 94609, United States|Novartis Investigative Site, Pasadena, California, 91101, United States|Novartis Investigative Site, Riverside, California, 92501, United States|Novartis Investigative Site, Spring Valley, California, 91978-1522, United States|Novartis Investigative Site, Torrance, California, 90502, United States|Novartis Investigative Site, Walnut Creek, California, 94598, United States|Novartis Investigative Site, Denver, Colorado, 80209, United States|Novartis Investigative Site, Bridgeport, Connecticut, 06610, United States|Novartis Investigative Site, Aventura, Florida, 33180, United States|Novartis Investigative Site, Boca Raton, Florida, 33433, United States|Novartis Investigative Site, Ft. Lauderdale, Florida, 33311, United States|Novartis Investigative Site, Hollywood, Florida, 33021, United States|Novartis Investigative Site, Jacksonville, Florida, 32204, United States|Novartis Investigative Site, Jacksonville, Florida, 32205, United States|Novartis Investigative Site, Jacksonville, Florida, 32209, United States|Novartis Investigative Site, Jacksonville, Florida, 32216, United States|Novartis Investigative Site, Lauderdale Lakes, Florida, 33313, United States|Novartis Investigative Site, Pensacola, Florida, 32504, United States|Novartis Investigative Site, Plantation, Florida, 33324, United States|Novartis Investigative Site, West Palm Beach, Florida, 33401, United States|Novartis Investigative Site, Atlanta, Georgia, 30309, United States|Novartis Investigative Site, Augusta, Georgia, 30904, United States|Novartis Investigative Site, Augusta, Georgia, 30909, United States|Novartis Investigative Site, Cumming, Georgia, 30041, United States|Novartis Investigative Site, Honolulu, Hawaii, 96813, United States|Novartis Investigative Site, Honolulu, Hawaii, 96814, United States|Novartis Investigative Site, Champaign, Illinois, 61820, United States|Novartis Investigative Site, Lake Zurich, Illinois, 60047, United States|Novartis Investigative Site, Peoria, Illinois, 61615, United States|Novartis Investigative Site, Topeka, Kansas, 66606, United States|Novartis Investigative Site, Louisville, Kentucky, 40202, United States|Novartis Investigative Site, Metairie, Louisiana, 70006, United States|Novartis Investigative Site, Slidell, Louisiana, 70458, United States|Novartis Investigative Site, Baltimore, Maryland, 21204, United States|Novartis Investigative Site, Burlington, Massachusetts, 01803, United States|Novartis Investigative Site, Haverhill, Massachusetts, 01830, United States|Novartis Investigative Site, Jamaica Plain, Massachusetts, 02130, United States|Novartis Investigative Site, Natick, Massachusetts, 01760, United States|Novartis Investigative Site, North Dartmouth, Massachusetts, 02747, United States|Novartis Investigative Site, Waltham, Massachusetts, 02154, United States|Novartis Investigative Site, Worcester, Massachusetts, 01609, United States|Novartis Investigative Site, Ann Arbor, Michigan, 48109, United States|Novartis Investigative Site, Detroit, Michigan, 48202, United States|Novartis Investigative Site, Detroit, Michigan, 48236, United States|Novartis Investigative Site, Kalamazoo, Michigan, 49048, United States|Novartis Investigative Site, Livonia, Michigan, 48154, United States|Novartis Investigative Site, Minneapolis, Minnesota, 55404, United States|Novartis Investigative Site, Minneapolis, Minnesota, 55455, United States|Novartis Investigative Site, St. Louis Park, Minnesota, 55416, United States|Novartis Investigative Site, Belzoni, Mississippi, 39038, United States|Novartis Investigative Site, Gulfport, Mississippi, 39501, United States|Novartis Investigative Site, Jackson, Mississippi, 39209, United States|Novartis Investigative Site, Springfield, Missouri, 65807, United States|Novartis Investigative Site, St. Louis, Missouri, 63110-1093, United States|Novartis Investigative Site, St. Louis, Missouri, 63141, United States|Novartis Investigative Site, Fremont, Nebraska, 68025, United States|Novartis Investigative Site, Omaha, Nebraska, 68131, United States|Novartis Investigative Site, Dover, New Hampshire, 03820-2403, United States|Novartis Investigative Site, Princeton Junction, New Jersey, 08550, United States|Novartis Investigative Site, Albuquerque, New Mexico, 87106, United States|Novartis Investigative Site, Albany, New York, 12206, United States|Novartis Investigative Site, Rochester, New York, 14607, United States|Novartis Investigative Site, Cincinnati, Ohio, 45236, United States|Novartis Investigative Site, Cleveland, Ohio, 44115, United States|Novartis Investigative Site, Lyndhurst, Ohio, 44124, United States|Novartis Investigative Site, Norman, Oklahoma, 73069, United States|Novartis Investigative Site, Oklahoma City, Oklahoma, 73112, United States|Novartis Investigative Site, Tulsa, Oklahoma, 74133, United States|Novartis Investigative Site, Allentown, Pennsylvania, 18103, United States|Novartis Investigative Site, Lancaster, Pennsylvania, 17604, United States|Novartis Investigative Site, Lansdale, Pennsylvania, 19446, United States|Novartis Investigative Site, Melrose Park, Pennsylvania, 19027, United States|Novartis Investigative Site, Philadelphia, Pennsylvania, 19138, United States|Novartis Investigative Site, Wyomissing, Pennsylvania, 19610, United States|Novartis Investigative Site, Warwick, Rhode Island, 02886, United States|Novartis Investigative Site, Aiken, South Carolina, 29801, United States|Novartis Investigative Site, Charleston, South Carolina, 29425, United States|Novartis Investigative Site, Columbia, South Carolina, 29201, United States|Novartis Investigative Site, Greenville, South Carolina, 29605, United States|Novartis Investigative Site, Orangeburg, South Carolina, 29115, United States|Novartis Investigative Site, Collierville, Tennessee, 38017, United States|Novartis Investigative Site, Amarillo, Texas, 79106, United States|Novartis Investigative Site, Austin, Texas, 78731, United States|Novartis Investigative Site, Dallas, Texas, 75226, United States|Novartis Investigative Site, Dallas, Texas, 75231, United States|Novartis Investigative Site, Dallas, Texas, 75235, United States|Novartis Investigative Site, Dallas, Texas, 75390, United States|Novartis Investigative Site, Houston, Texas, 77030, United States|Novartis Investigative Site, Irving, Texas, 75039, United States|Novartis Investigative Site, McAllen, Texas, 78501, United States|Novartis Investigative Site, North Richland Hills, Texas, 76180, United States|Novartis Investigative Site, Plano, Texas, 75024, United States|Novartis Investigative Site, San Antonio, Texas, 78207, United States|Novartis Investigative Site, San Antonio, Texas, 78218, United States|Novartis Investigative Site, San Antonio, Texas, 78229-4801, United States|Novartis Investigative Site, Temple, Texas, 76508-0002, United States|Novartis Investigative Site, Bennington, Vermont, 05201, United States|Novartis Investigative Site, Burlington, Vermont, 05401, United States|Novartis Investigative Site, Alexandria, Virginia, 22304-2315, United States|Novartis Investigative Site, Burke, Virginia, 22015, United States|Novartis Investigative Site, Renton, Washington, 98055, United States|Novartis Investigative Site, Charleston, West Virginia, 25301, United States|Novartis Investigative Site, Appleton, Wisconsin, 54911, United States|Novartis Investigative Site, Caba, Buenos Aires, 1428, Argentina|Novartis Investigative Site, Caba, Buenos Aires, C1181ACH, Argentina|Novartis Investigative Site, Caba, Buenos Aires, C1280AEB, Argentina|Novartis Investigative Site, Caba, Buenos Aires, C1408INH, Argentina|Novartis Investigative Site, Caba, Buenos Aires, C1416DRJ, Argentina|Novartis Investigative Site, Caba, Buenos Aires, C1425AST, Argentina|Novartis Investigative Site, Florida, Buenos Aires, B1602BPD, Argentina|Novartis Investigative Site, Lanus, Buenos Aires, B8000XAV, Argentina|Novartis Investigative Site, Ramos Mejia, Buenos Aires, B1704ETD, Argentina|Novartis Investigative Site, Zarate, Buenos Aires, 2800, Argentina|Novartis Investigative Site, Rosario, Santa Fe, S2000AII, Argentina|Novartis Investigative Site, Rosario, Santa Fe, S2000CXH, Argentina|Novartis Investigative Site, Rosario, Santa Fe, S2000DFD, Argentina|Novartis Investigative Site, Rosario, Santa Fe, S2001ODA, Argentina|Novartis Investigative Site, Rosario, Santa Fe, S200CVD, Argentina|Novartis Investigative Site, Buenos aires, C1120AAC, Argentina|Novartis Investigative Site, Buenos Aires, C1405BCH, Argentina|Novartis Investigative Site, Cordoba, 5000, Argentina|Novartis Investigative Site, Cordoba, X5000AAW, Argentina|Novartis Investigative Site, Cordoba, X5000EVQ, Argentina|Novartis Investigative Site, Cordoba, X5000FGG, Argentina|Novartis Investigative Site, Cordoba, X5000IUG, Argentina|Novartis Investigative Site, Cordoba, X5000JHQ, Argentina|Novartis Investigative Site, Cordoba, X5009BSN, Argentina|Novartis Investigative Site, Cordoba, X5016KEH, Argentina|Novartis Investigative Site, Corrientes, W3400, Argentina|Novartis Investigative Site, Santa Fe, S3000FNF, Argentina|Novartis Investigative Site, Santa Fe, S3000FSO, Argentina|Novartis Investigative Site, Santa Fe, S3000FVA, Argentina|Novartis Investigative Site, Bregenz, A-6900, Austria|Novartis Investigative Site, Feldkirch, 6807, Austria|Novartis Investigative Site, Graz, 8036, Austria|Novartis Investigative Site, Innsbruck, INNSBRUCK, Austria|Novartis Investigative Site, Salzburg, A-5020, Austria|Novartis Investigative Site, Vienna, 1030, Austria|Novartis Investigative Site, Wien, 1090, Austria|Novartis Investigative Site, Wien, A-1130, Austria|Novartis Investigative Site, Wien, A-1220, Austria|Novartis Investigative Site, Bonheiden, 2820, Belgium|Novartis Investigative Site, Brugge, 8000, Belgium|Novartis Investigative Site, Brussel, 9100, Belgium|Novartis Investigative Site, Bruxelles, 1070, Belgium|Novartis Investigative Site, Bruxelles, 1200, Belgium|Novartis Investigative Site, Charleroi, 6000, Belgium|Novartis Investigative Site, De Pinte, 9840, Belgium|Novartis Investigative Site, Edegem, 2650, Belgium|Novartis Investigative Site, Genk, 3600, Belgium|Novartis Investigative Site, Gent, 9000, Belgium|Novartis Investigative Site, Hasselt, 3500, Belgium|Novartis Investigative Site, Kortrijk, 8500, Belgium|Novartis Investigative Site, La Louvière, 7100, Belgium|Novartis Investigative Site, Leuven, 3000, Belgium|Novartis Investigative Site, Liege, 4000, Belgium|Novartis Investigative Site, Roeselare, 8800, Belgium|Novartis Investigative Site, Ronse, 9600, Belgium|Novartis Investigative Site, Seraing, 4100, Belgium|Novartis Investigative Site, Sint-Gillis-Waas, 9170, Belgium|Novartis Investigative Site, Turnhout, 2300, Belgium|Novartis Investigative Site, Vilvoorde, 1800, Belgium|Novartis Investigative Site, Willebroek, 2830, Belgium|Novartis Investigative Site, Salvador, BA, 40050-410, Brazil|Novartis Investigative Site, Fortaleza, CE, 60120-021, Brazil|Novartis Investigative Site, Fortaleza, CE, 60430-370, Brazil|Novartis Investigative Site, Vitoria, ES, 29040-091, Brazil|Novartis Investigative Site, Juiz de Fora, MG, 36036-110, Brazil|Novartis Investigative Site, Belem, PA, 66073-000, Brazil|Novartis Investigative Site, Rio de Janeiro, RJ, 20020-020, Brazil|Novartis Investigative Site, Rio de Janeiro, RJ, 20551-030, Brazil|Novartis Investigative Site, Porto Alegre, RS, 90020-090, Brazil|Novartis Investigative Site, Campinas, SP, 13060-904, Brazil|Novartis Investigative Site, Campinas, SP, 13083-190, Brazil|Novartis Investigative Site, Marilia, SP, 17519-030, Brazil|Novartis Investigative Site, Santos, SP, 11045-904, Brazil|Novartis Investigative Site, Sao Jose do Rio Preto, SP, 15090-000, Brazil|Novartis Investigative Site, Sorocaba, SP, 18030-210, Brazil|Novartis Investigative Site, São Paulo, SP, 04023-900, Brazil|Novartis Investigative Site, São Paulo, SP, 05403-000, Brazil|Novartis Investigative Site, Edmonton, Alberta, T5J 3N4, Canada|Novartis Investigative Site, Edmonton, Alberta, T5N 3Y6, Canada|Novartis Investigative Site, Vancouver, British Columbia, V6E 1M7, Canada|Novartis Investigative Site, Winnipeg, Manitoba, R2V 4W3, Canada|Novartis Investigative Site, Winnipeg, Manitoba, R3E 3P4, Canada|Novartis Investigative Site, Bay Roberts, Newfoundland and Labrador, A0A 1G0, Canada|Novartis Investigative Site, St. John's, Newfoundland and Labrador, A1E 4J8, Canada|Novartis Investigative Site, Brampton, Ontario, L6Z 4N5, Canada|Novartis Investigative Site, Burlington, Ontario, L7M 4Y1, Canada|Novartis Investigative Site, Cambridge, Ontario, N1R 6V6, Canada|Novartis Investigative Site, Courtice, Ontario, L1E 3C3, Canada|Novartis Investigative Site, Etobicoke, Ontario, M9R 4E1, Canada|Novartis Investigative Site, London, Ontario, N6A 4G5, Canada|Novartis Investigative Site, North Bay, Ontario, P1B 2H3, Canada|Novartis Investigative Site, Oakville, Ontario, L6H 3P1, Canada|Novartis Investigative Site, Oshawa, Ontario, L1J 2K1, Canada|Novartis Investigative Site, Ottawa, Ontario, K1H 7W9, Canada|Novartis Investigative Site, Scarborough, Ontario, M1H 3G4, Canada|Novartis Investigative Site, Thornhill, Ontario, L4J 8L7, Canada|Novartis Investigative Site, Toronto, Ontario, M4G 3E8, Canada|Novartis Investigative Site, Toronto, Ontario, M4N 3M5, Canada|Novartis Investigative Site, Toronto, Ontario, M5C 2T2, Canada|Novartis Investigative Site, Toronto, Ontario, N6G 4X8, Canada|Novartis Investigative Site, Greenfield Park, Quebec, J4V 2H1, Canada|Novartis Investigative Site, Mirabel, Quebec, J7J 2K8, Canada|Novartis Investigative Site, Montreal, Quebec, H1T 2M4, Canada|Novartis Investigative Site, Pointe-Claire, Quebec, H9R 4S3, Canada|Novartis Investigative Site, Québec, Quebec, G1G 3Y8, Canada|Novartis Investigative Site, Sainte-Foy, Quebec, G1V 4G5, Canada|Novartis Investigative Site, Sainte-Foy, Quebec, G1W 4R4, Canada|Novartis Investigative Site, Sherbrooke, Quebec, J1G 5K2, Canada|Novartis Investigative Site, Ste-Foy, Quebec, G1V 4G2, Canada|Novartis Investigative Site, Trois-Rivières, Quebec, G8Z 3R9, Canada|Novartis Investigative Site, Saskatoon, Saskatchewan, S7H 5M3, Canada|Novartis Investigative Site, Ouest-Montreal, H2W1R7, Canada|Novartis Investigative Site, Beijing, Beijing, 100044, China|Novartis Investigative Site, Beijing, Beijing, 100083, China|Novartis Investigative Site, Beijing, Beijing, 100730, China|Novartis Investigative Site, Chongqing, Chongqing, 400016, China|Novartis Investigative Site, Chongqing, Chongqing, China|Novartis Investigative Site, Fuzhou, Fujian, 350025, China|Novartis Investigative Site, Guangzhou, Guangdong, 510180, China|Novartis Investigative Site, Shijiazhuang, Hebei, 050051, China|Novartis Investigative Site, Harbin, Heilongjiang, 150001, China|Novartis Investigative Site, Harbin, Heilongjiang, 150086, China|Novartis Investigative Site, Wuhan, Hubei, 430030, China|Novartis Investigative Site, Changsha City, Hunan, 410011, China|Novartis Investigative Site, Changsha, Hunan, 410008, China|Novartis Investigative Site, Nanjing, Jiangsu, 210006, China|Novartis Investigative Site, Nanjing, Jiangsu, 210008, China|Novartis Investigative Site, Nanjing, Jiangsu, 210009, China|Novartis Investigative Site, Nanjing, Jiangsu, 210029, China|Novartis Investigative Site, Suzhou, Jiangsu, 215004, China|Novartis Investigative Site, Dalian, Liaoning, 116011, China|Novartis Investigative Site, Shenyang, Liaoning, 110003, China|Novartis Investigative Site, Qingdao, Shandong, 266011, China|Novartis Investigative Site, Xi'an, Shanxi, 710032, China|Novartis Investigative Site, Xi'an, Shanxi, 710061, China|Novartis Investigative Site, Chengdu, Sichuan, 610041, China|Novartis Investigative Site, Kunming, Yunnan, 650101, China|Novartis Investigative Site, Hangzhou, Zhejiang, 310003, China|Novartis Investigative Site, Hangzhou, Zhejiang, 310009, China|Novartis Investigative Site, Hangzhou, Zhejiang, 310013, China|Novartis Investigative Site, Hangzhou, Zhejiang, 310016, China|Novartis Investigative Site, Beijing, 100028, China|Novartis Investigative Site, Beijing, 100029, China|Novartis Investigative Site, Beijing, 100034, China|Novartis Investigative Site, Beijing, 100088, China|Novartis Investigative Site, Beijing, 100176, China|Novartis Investigative Site, Beijing, China|Novartis Investigative Site, Chengdu, 610072, China|Novartis Investigative Site, Chongqing, 400038, China|Novartis Investigative Site, Dalian, China|Novartis Investigative Site, Guangzhou, 510000, China|Novartis Investigative Site, Shanghai, 200003, China|Novartis Investigative Site, Shanghai, 200025, China|Novartis Investigative Site, Shanghai, 200031, China|Novartis Investigative Site, Shanghai, 200233, China|Novartis Investigative Site, Tianjin, 300052, China|Novartis Investigative Site, Tianjin, 300142, China|Novartis Investigative Site, Bogotá, Colombia|Novartis Investigative Site, Cali, Colombia|Novartis Investigative Site, Florida Blanca, Colombia|Novartis Investigative Site, Medellín, Colombia|Novartis Investigative Site, Brno-Bohunice, 639 01, Czech Republic|Novartis Investigative Site, Brno, 61300, Czech Republic|Novartis Investigative Site, Ceske Budejovice, 370 87, Czech Republic|Novartis Investigative Site, Ostrava, 702 00, Czech Republic|Novartis Investigative Site, Pardubice, 53002, Czech Republic|Novartis Investigative Site, Pisek, 397 01, Czech Republic|Novartis Investigative Site, Prague 2, 128 02, Czech Republic|Novartis Investigative Site, Prague 2, 128 08, Czech Republic|Novartis Investigative Site, Prague 4 - Krc, 14059, Czech Republic|Novartis Investigative Site, Prague 5 - Motol, 15112, Czech Republic|Novartis Investigative Site, Aalborg, DK-9100, Denmark|Novartis Investigative Site, Copenhagen NV, DK-2400, Denmark|Novartis Investigative Site, Frederiksberg, DK-2000, Denmark|Novartis Investigative Site, Gentofte, DK-2820, Denmark|Novartis Investigative Site, Hillerød, DK-3400, Denmark|Novartis Investigative Site, Hvidovre, 2650, Denmark|Novartis Investigative Site, Roskilde, DK-4000, Denmark|Novartis Investigative Site, Slagelse, DK-4200, Denmark|Novartis Investigative Site, Svendborg, DK-5700, Denmark|Novartis Investigative Site, Århus, DK-8000, Denmark|Novartis Investigative Site, Helsinki, 00250, Finland|Novartis Investigative Site, Hyvinkää, FIN-05850, Finland|Novartis Investigative Site, Kajaani, FIN-87140, Finland|Novartis Investigative Site, Kuopio, FIN-70211, Finland|Novartis Investigative Site, Lohja, FIN-08200, Finland|Novartis Investigative Site, Oulu, 90100, Finland|Novartis Investigative Site, OYS, FIN-90029, Finland|Novartis Investigative Site, Pori, 28120, Finland|Novartis Investigative Site, Tammisaari, 10600, Finland|Novartis Investigative Site, Tampere, 33520, Finland|Novartis Investigative Site, Valkeakoski, 37600, Finland|Novartis Investigative Site, Besancon Cedex, 25030, France|Novartis Investigative Site, Bondy, 93143, France|Novartis Investigative Site, Corbeil Essonnes, 91100, France|Novartis Investigative Site, Grenoble, 38043, France|Novartis Investigative Site, La Rochelle, 17019, France|Novartis Investigative Site, Lagny sur Marne, 77405, France|Novartis Investigative Site, Limoges Cedex, 87042, France|Novartis Investigative Site, Lyon Cedex 03, 69394, France|Novartis Investigative Site, Lyon, 69437, France|Novartis Investigative Site, Paris cedex 18, 75877, France|Novartis Investigative Site, Paris Cedex 4, 75181, France|Novartis Investigative Site, Poitiers Cedex, 86021, France|Novartis Investigative Site, Aschaffenburg, 63739, Germany|Novartis Investigative Site, Aschaffenburg, 63741, Germany|Novartis Investigative Site, Asslar, 35614, Germany|Novartis Investigative Site, Bad Oeynhausen, 32545, Germany|Novartis Investigative Site, Barsinghausen, 30890, Germany|Novartis Investigative Site, Bensheim, 64625, Germany|Novartis Investigative Site, Berlin, 13055, Germany|Novartis Investigative Site, Berlin, 13597, Germany|Novartis Investigative Site, Berlin, 14193, Germany|Novartis Investigative Site, Bonn, 53105, Germany|Novartis Investigative Site, Bottrop, 46242, Germany|Novartis Investigative Site, Bremen, 28277, Germany|Novartis Investigative Site, Bretten, 75015, Germany|Novartis Investigative Site, Cloppenburg, 49661, Germany|Novartis Investigative Site, Dippoldiswalde, 01744, Germany|Novartis Investigative Site, Dresden, 01127, Germany|Novartis Investigative Site, Dresden, 01307, Germany|Novartis Investigative Site, Duesseldorf, 40210, Germany|Novartis Investigative Site, Essen, 45127, Germany|Novartis Investigative Site, Essen, 45134, Germany|Novartis Investigative Site, Essen, 45138, Germany|Novartis Investigative Site, Fuldatal, 34233, Germany|Novartis Investigative Site, Göttingen, 37075, Germany|Novartis Investigative Site, Hagen, 58095, Germany|Novartis Investigative Site, Hamburg, 22335, Germany|Novartis Investigative Site, Hamburg, 22393, Germany|Novartis Investigative Site, Hannover, 30625, Germany|Novartis Investigative Site, Heidelberg, 69120, Germany|Novartis Investigative Site, Heilbronn, 74072, Germany|Novartis Investigative Site, Heilbronn, 74076, Germany|Novartis Investigative Site, Ingelheim, 55218, Germany|Novartis Investigative Site, Jena, 07743, Germany|Novartis Investigative Site, Kassel, 34117, Germany|Novartis Investigative Site, Krefeld, 47798, Germany|Novartis Investigative Site, Magdeburg, 39120, Germany|Novartis Investigative Site, Mainz, 55131, Germany|Novartis Investigative Site, Messkirch, 88605, Germany|Novartis Investigative Site, Muehldorf am Inn, 84453, Germany|Novartis Investigative Site, Neuwied, 56564, Germany|Novartis Investigative Site, Offenbach, 63065, Germany|Novartis Investigative Site, Rehburg-Loccum, 31547, Germany|Novartis Investigative Site, Riesa, 01587, Germany|Novartis Investigative Site, Schauenburg-Elgershausen, 34270, Germany|Novartis Investigative Site, Schwabenheim, 55270, Germany|Novartis Investigative Site, St. Ingbert - Oberwuerzbach, 66386, Germany|Novartis Investigative Site, Ursensollen, 92289, Germany|Novartis Investigative Site, Wetter, 58300, Germany|Novartis Investigative Site, Wiehl, 51674, Germany|Novartis Investigative Site, Wiesbaden, 65183, Germany|Novartis Investigative Site, Wuerzburg, 97072, Germany|Novartis Investigative Site, Alexandroupolis, GR 68 100, Greece|Novartis Investigative Site, Athens - GR, 10676, Greece|Novartis Investigative Site, Athens, GR 115 21, Greece|Novartis Investigative Site, Athens, GR 115 22, Greece|Novartis Investigative Site, Athens, GR 115 27, Greece|Novartis Investigative Site, Athens, GR 11527, Greece|Novartis Investigative Site, Athens, Greece|Novartis Investigative Site, Ioannina, GR 45500, Greece|Novartis Investigative Site, Patras, 26500, Greece|Novartis Investigative Site, Piraeurs, GR 184 54, Greece|Novartis Investigative Site, Thessaloniki, 57001, Greece|Novartis Investigative Site, Thessaloniki, GR 546 39, Greece|Novartis Investigative Site, Guatemala City, 01001, Guatemala|Novartis Investigative Site, Guatemala City, 01010, Guatemala|Novartis Investigative Site, Guatemala City, 01011, Guatemala|Novartis Investigative Site, Guatemala City, 01015, Guatemala|Novartis Investigative Site, Baja, 6500, Hungary|Novartis Investigative Site, Balatonfured, 8230, Hungary|Novartis Investigative Site, Budapest, 1062, Hungary|Novartis Investigative Site, Budapest, 1083, Hungary|Novartis Investigative Site, Budapest, 1085, Hungary|Novartis Investigative Site, Budapest, 1096, Hungary|Novartis Investigative Site, Budapest, 1115, Hungary|Novartis Investigative Site, Budapest, H-1032, Hungary|Novartis Investigative Site, Debrecen, 4004, Hungary|Novartis Investigative Site, Debrecen, 4032, Hungary|Novartis Investigative Site, Gyula, 5703, Hungary|Novartis Investigative Site, Kaposvar, 7400, Hungary|Novartis Investigative Site, Miskolc, 3526, Hungary|Novartis Investigative Site, Pecs, 7324, Hungary|Novartis Investigative Site, Szeged, 6720, Hungary|Novartis Investigative Site, Zalaegerszeg, 8900, Hungary|Novartis Investigative Site, Hyderabad, Andhra Pradesh, INDIA, 500034, India|Novartis Investigative Site, Hyderabad, Andhra Pradesh, 500001, India|Novartis Investigative Site, Hyderabad, Andhra Pradesh, 500012, India|Novartis Investigative Site, Hyderabad, Andhra Pradesh, 500018, India|Novartis Investigative Site, Ahmedabad, Gujarat, 380014, India|Novartis Investigative Site, Bangalore, Karnataka, 560054, India|Novartis Investigative Site, Banglaore, Karnataka, 560038, India|Novartis Investigative Site, Mangalore, Karnataka, 575001, India|Novartis Investigative Site, Kochi, Kerala, 682 026, India|Novartis Investigative Site, Mumbai, Maharashtra, 400008, India|Novartis Investigative Site, Pune, Maharashtra, 411011, India|Novartis Investigative Site, Pune, Maharashtra, 411030, India|Novartis Investigative Site, Chennai, Tamil Nadu, 600013, India|Novartis Investigative Site, Vellore, Tamil Nadu, 632004, India|Novartis Investigative Site, Bangalore, 560 034, India|Novartis Investigative Site, Chennai, 600010, India|Novartis Investigative Site, Chennai, 600086, India|Novartis Investigative Site, Hyderabad, 500 063, India|Novartis Investigative Site, Kolkota, 700020, India|Novartis Investigative Site, New Delhi, 110 029, India|Novartis Investigative Site, L'Aquila, AQ, 67100, Italy|Novartis Investigative Site, Bergamo, BG, 24128, Italy|Novartis Investigative Site, Belluno, BL, 32100, Italy|Novartis Investigative Site, Bologna, BO, 40138, Italy|Novartis Investigative Site, Campobasso, CB, 86100, Italy|Novartis Investigative Site, Caserta, CE, 81100, Italy|Novartis Investigative Site, Chieti, CH, 66100, Italy|Novartis Investigative Site, Cuneo, CN, 12100, Italy|Novartis Investigative Site, Cosenza, CS, 87100, Italy|Novartis Investigative Site, Catanzaro, CZ, 88100, Italy|Novartis Investigative Site, Cona, FE, 44100, Italy|Novartis Investigative Site, Foggia, FG, 71100, Italy|Novartis Investigative Site, Firenze, FI, 50134, Italy|Novartis Investigative Site, Arenzano, GE, 16011, Italy|Novartis Investigative Site, Genova, GE, 16132, Italy|Novartis Investigative Site, Pozzilli, IS, 86077, Italy|Novartis Investigative Site, Lecco, LC, 23900, Italy|Novartis Investigative Site, Monza, MB, 20900, Italy|Novartis Investigative Site, Milano, MI, 20123, Italy|Novartis Investigative Site, Milano, MI, 20132, Italy|Novartis Investigative Site, Milano, MI, 20146, Italy|Novartis Investigative Site, Milano, MI, 20157, Italy|Novartis Investigative Site, Passirana di Rho, MI, 20017, Italy|Novartis Investigative Site, Palermo, PA, 90127, Italy|Novartis Investigative Site, Perugia, PG, 06100, Italy|Novartis Investigative Site, Pisa, PI, 56124, Italy|Novartis Investigative Site, Pisa, PI, 56126, Italy|Novartis Investigative Site, Pordenone, PN, 33170, Italy|Novartis Investigative Site, Parma, PR, 43100, Italy|Novartis Investigative Site, Casorate Primo, PV, 27022, Italy|Novartis Investigative Site, Pavia, PV, 27100, Italy|Novartis Investigative Site, Stradella, PV, 27049, Italy|Novartis Investigative Site, Ravenna, RA, 48100, Italy|Novartis Investigative Site, Roma, RM, 00122, Italy|Novartis Investigative Site, Roma, RM, 00133, Italy|Novartis Investigative Site, Roma, RM, 00157, Italy|Novartis Investigative Site, Roma, RM, 00161, Italy|Novartis Investigative Site, Roma, RM, 00163, Italy|Novartis Investigative Site, Roma, RM, 00186, Italy|Novartis Investigative Site, Roma, RM, 00189, Italy|Novartis Investigative Site, Cava De' Tirreni, SA, 84013, Italy|Novartis Investigative Site, Mercato San Severino, SA, 84085, Italy|Novartis Investigative Site, Salerno, SA, 84125, Italy|Novartis Investigative Site, Siena, SI, 53100, Italy|Novartis Investigative Site, Olbia, SS, 07026, Italy|Novartis Investigative Site, Sassari, SS, 07100, Italy|Novartis Investigative Site, Torino, TO, 10126, Italy|Novartis Investigative Site, Torino, TO, 10128, Italy|Novartis Investigative Site, Torino, TO, 10154, Italy|Novartis Investigative Site, Vittorio Veneto, TV, 31029, Italy|Novartis Investigative Site, San Daniele Del Friuli, UD, 33038, Italy|Novartis Investigative Site, Udine, UD, 33100, Italy|Novartis Investigative Site, Venezia, VE, 30174, Italy|Novartis Investigative Site, Verona, VR, 37126, Italy|Novartis Investigative Site, Isernia, 86170, Italy|Novartis Investigative Site, Napoli, 80131, Italy|Novartis Investigative Site, Nagoya, Aichi, 451-8511, Japan|Novartis Investigative Site, Nagoya, Aichi, 455-8530, Japan|Novartis Investigative Site, Nagoya, Aichi, 460-0001, Japan|Novartis Investigative Site, Nagoya, Aichi, 462-0802, Japan|Novartis Investigative Site, Nagoya, Aichi, 462-0825, Japan|Novartis Investigative Site, Asahi, Chiba, 289-2511, Japan|Novartis Investigative Site, Kasuga, Fukuoka, 816-0864, Japan|Novartis Investigative Site, Kitakyushu, Fukuoka, 800-0296, Japan|Novartis Investigative Site, Koriyama-city, Fukushima, 963-8851, Japan|Novartis Investigative Site, Asahikawa, Hokkaido, 078-8211, Japan|Novartis Investigative Site, Sapporo-city, Hokkaido, 060-8648, Japan|Novartis Investigative Site, Sapporo, Hokkaido, 003-0023, Japan|Novartis Investigative Site, Sapporo, Hokkaido, 060-0033, Japan|Novartis Investigative Site, Toride-city, Ibaraki, 302-0022, Japan|Novartis Investigative Site, Takamatsu, Kagawa, 7600076, Japan|Novartis Investigative Site, Aira-city, Kagoshima, 899-5431, Japan|Novartis Investigative Site, Isehara-city, Kanagawa, 259-1131, Japan|Novartis Investigative Site, Kawasaki, Kanagawa, 210-0852, Japan|Novartis Investigative Site, Yatsushiro, Kumamoto, 866-8660, Japan|Novartis Investigative Site, Kyoto-city, Kyoto, 612-8555, Japan|Novartis Investigative Site, Kyoto-city, Kyoto, 615-0035, Japan|Novartis Investigative Site, Sendai-city, Miyagi, 980-8574, Japan|Novartis Investigative Site, Suwa, Nagano, 392-8510, Japan|Novartis Investigative Site, Okayama-city, Okayama, 700-8558, Japan|Novartis Investigative Site, Takatsuki-city, Osaka, 569-1096, Japan|Novartis Investigative Site, Toyonaka, Osaka, 561-0871, Japan|Novartis Investigative Site, Yao-city, Osaka, 581-0011, Japan|Novartis Investigative Site, Tokorozawa, Saitama, 351-1151, Japan|Novartis Investigative Site, Ohtsu-city, Shiga, 520-2192, Japan|Novartis Investigative Site, Shimizu, Shizuoka, 411-8611, Japan|Novartis Investigative Site, Bunkyo-ku, Tokyo, 113-8655, Japan|Novartis Investigative Site, Chuo-ku, Tokyo, 103-0002, Japan|Novartis Investigative Site, Takaoka, Toyama, 933-0955, Japan|Novartis Investigative Site, Oita, 870-0039, Japan|Novartis Investigative Site, Oita, 870-0192, Japan|Novartis Investigative Site, Okayama, 701-1192, Japan|Novartis Investigative Site, Ansan, Gyeonggi-do, 425-801, Korea, Republic of|Novartis Investigative Site, Anyang, Gyeonggi-do, 431-070, Korea, Republic of|Novartis Investigative Site, Seoul, Korea, 110 744, Korea, Republic of|Novartis Investigative Site, Seoul, Korea, 120-752, Korea, Republic of|Novartis Investigative Site, Seoul, Korea, 135-710, Korea, Republic of|Novartis Investigative Site, Bundang, Seongnam, 463-707, Korea, Republic of|Novartis Investigative Site, Busan, 602-739, Korea, Republic of|Novartis Investigative Site, Daejeon, 301-747, Korea, Republic of|Novartis Investigative Site, Incheon, 400-712, Korea, Republic of|Novartis Investigative Site, Pusan, 614-735, Korea, Republic of|Novartis Investigative Site, Seoul, 135-720, Korea, Republic of|Novartis Investigative Site, Seoul, 136 705, Korea, Republic of|Novartis Investigative Site, Seoul, 137-701, Korea, Republic of|Novartis Investigative Site, Seoul, 152-703, Korea, Republic of|Novartis Investigative Site, Seoul, 156-707, Korea, Republic of|Novartis Investigative Site, Taegu, 700 - 721, Korea, Republic of|Novartis Investigative Site, Kaunas, 50009, Lithuania|Novartis Investigative Site, Klaipeda, 92304, Lithuania|Novartis Investigative Site, Vilnius, LT-08661, Lithuania|Novartis Investigative Site, Vilnius, Lithuania|Novartis Investigative Site, Alkmaar, 1851 JD, Netherlands|Novartis Investigative Site, Almelo, 7609 PP, Netherlands|Novartis Investigative Site, Amersfoort, 3800 BM, Netherlands|Novartis Investigative Site, Amsterdam, 1061 AE, Netherlands|Novartis Investigative Site, Apeldoorn, 7334 DZ, Netherlands|Novartis Investigative Site, Arnhem, 6815 AD, Netherlands|Novartis Investigative Site, Breda, 4818 CK, Netherlands|Novartis Investigative Site, Delft, 2625 AD, Netherlands|Novartis Investigative Site, Den Helder, 1782 GZ, Netherlands|Novartis Investigative Site, Deventer, 7416 SE, Netherlands|Novartis Investigative Site, Doetinchem, 7009 BL, Netherlands|Novartis Investigative Site, Dordrecht, 3318AT, Netherlands|Novartis Investigative Site, Eindhoven, 5623 EJ, Netherlands|Novartis Investigative Site, Eindhoven, 5631 BM, Netherlands|Novartis Investigative Site, Goes, 4462 RA, Netherlands|Novartis Investigative Site, Groningen, 9713 GZ, Netherlands|Novartis Investigative Site, Heerlen, 6419 PC, Netherlands|Novartis Investigative Site, Hoogeveen, 7909 AA, Netherlands|Novartis Investigative Site, Hoogwoud, 1718 BG, Netherlands|Novartis Investigative Site, Losser, 7581 BV, Netherlands|Novartis Investigative Site, Meppel, 7943 KA, Netherlands|Novartis Investigative Site, Nieuwegein, 3435 CM, Netherlands|Novartis Investigative Site, Oude Pekela, 9665 AR, Netherlands|Novartis Investigative Site, Rotterdam, 3015 CE, Netherlands|Novartis Investigative Site, Rotterdam, 3045 PM, Netherlands|Novartis Investigative Site, Rotterdam, 3083 AN, Netherlands|Novartis Investigative Site, Tiel, 4002 WP, Netherlands|Novartis Investigative Site, Utrecht, 3508 GA, Netherlands|Novartis Investigative Site, Venlo, 5912 BL, Netherlands|Novartis Investigative Site, Woerden, 3443 GG, Netherlands|Novartis Investigative Site, Zwijndrecht, NL-3331 LZ, Netherlands|Novartis Investigative Site, Zwolle, 8025 AB, Netherlands|Novartis Investigative Site, Bergen, 5013, Norway|Novartis Investigative Site, Fredrikstad, 1607, Norway|Novartis Investigative Site, Horten, 3191, Norway|Novartis Investigative Site, Hønefoss, 3515, Norway|Novartis Investigative Site, Oslo, 0160, Norway|Novartis Investigative Site, Skedsmokorset, 2020, Norway|Novartis Investigative Site, Skien, 3722, Norway|Novartis Investigative Site, Spikkestad, 3430, Norway|Novartis Investigative Site, Stavanger, 4011, Norway|Novartis Investigative Site, Svelvik, 3060, Norway|Novartis Investigative Site, Tromsø, NO-9038, Norway|Novartis Investigative Site, Trondheim, NO-7011, Norway|Novartis Investigative Site, Tønsberg, 3103, Norway|Novartis Investigative Site, Bellavista, Lima, Callao 02, Peru|Novartis Investigative Site, Cercado de Lima, Lima, 01, Peru|Novartis Investigative Site, San Borja, Lima, 41, Peru|Novartis Investigative Site, San Isidro, Lima, 27, Peru|Novartis Investigative Site, San Martin de Porres, Lima, 31, Peru|Novartis Investigative Site, Santiago de Surco, Lima, 33, Peru|Novartis Investigative Site, Almada, 2801-951, Portugal|Novartis Investigative Site, Amadora, 2720-276, Portugal|Novartis Investigative Site, Coimbra, 3000-075, Portugal|Novartis Investigative Site, Linda-a-Velha, 2799-523, Portugal|Novartis Investigative Site, Lisboa, 1169-024, Portugal|Novartis Investigative Site, Lisboa, 1250-203, Portugal|Novartis Investigative Site, Lisboa, 1495-005, Portugal|Novartis Investigative Site, Lisboa, 1649-035, Portugal|Novartis Investigative Site, Matosinhos, 4454-509, Portugal|Novartis Investigative Site, Portimão, 8500-388, Portugal|Novartis Investigative Site, Porto, 4200-319, Portugal|Novartis Investigative Site, Santa Maria da Feira, 4520-211, Portugal|Novartis Investigative Site, Santarém, 2000-153, Portugal|Novartis Investigative Site, Ponce, 00716, Puerto Rico|Novartis Investigative Site, Ponce, 00733-1471, Puerto Rico|Novartis Investigative Site, Singapore, 119074, Singapore|Novartis Investigative Site, Singapore, 159964, Singapore|Novartis Investigative Site, Singapore, 168752, Singapore|Novartis Investigative Site, Singapore, 169608, Singapore|Novartis Investigative Site, Singapore, 308433, Singapore|Novartis Investigative Site, Bratislava, Slovak Republic, 826 06, Slovakia|Novartis Investigative Site, Kosice, Slovak Republic, 040 22, Slovakia|Novartis Investigative Site, Zilina, Slovak Republic, 010 01, Slovakia|Novartis Investigative Site, Banksa Bystrica, SK 97 517, Slovakia|Novartis Investigative Site, Bratislava, 811 08, Slovakia|Novartis Investigative Site, Bratislava, 812 72, Slovakia|Novartis Investigative Site, Bratislava, 81369, Slovakia|Novartis Investigative Site, Bratislava, 833 48, Slovakia|Novartis Investigative Site, Bratislava, 851 07, Slovakia|Novartis Investigative Site, Kosice, 040 01, Slovakia|Novartis Investigative Site, Lubochna, SK 03491, Slovakia|Novartis Investigative Site, Lucenec, 98439, Slovakia|Novartis Investigative Site, Martin, 03601, Slovakia|Novartis Investigative Site, Nitra, 949 01, Slovakia|Novartis Investigative Site, Piestany, 921 01, Slovakia|Novartis Investigative Site, Prievidza, 971 01, Slovakia|Novartis Investigative Site, Trstena, 549 16, Slovakia|Novartis Investigative Site, Somerset West, Western Cape, 7130, South Africa|Novartis Investigative Site, Cape Town, 7925, South Africa|Novartis Investigative Site, Durban, 4001, South Africa|Novartis Investigative Site, Durban, 4030, South Africa|Novartis Investigative Site, Durban, 4052, South Africa|Novartis Investigative Site, Durban, 4110, South Africa|Novartis Investigative Site, Gauteng, South Africa|Novartis Investigative Site, Johannesburg, 2196, South Africa|Novartis Investigative Site, Port Elizabeth, 6001, South Africa|Novartis Investigative Site, Pretoria, 0002, South Africa|Novartis Investigative Site, Cadiz, Andalucia, 11010, Spain|Novartis Investigative Site, Granada, Andalucia, 18014, Spain|Novartis Investigative Site, Jerez de La Frontera, Andalucia, 11407, Spain|Novartis Investigative Site, Malaga, Andalucia, 29010, Spain|Novartis Investigative Site, Malaga, Andalucia, 29018, Spain|Novartis Investigative Site, Málaga, Andalucia, 29010, Spain|Novartis Investigative Site, Puerto de Santa Maria, Andalucia, 11500, Spain|Novartis Investigative Site, Sanlúcar de Barrameda, Andalucia, 11540, Spain|Novartis Investigative Site, Sevilla, Andalucia, 41009, Spain|Novartis Investigative Site, Oviedo, Asturias, 33006, Spain|Novartis Investigative Site, Oviedo, Asturias, 33008, Spain|Novartis Investigative Site, Oviedo, Asturias, 33010, Spain|Novartis Investigative Site, Hospitalet de Llobregat, Barcelona, 08907, Spain|Novartis Investigative Site, Sabadell, Barcelona, 08208, Spain|Novartis Investigative Site, Alcazar de San Juan, Castilla la Mancha, 13600, Spain|Novartis Investigative Site, Aranda de Duero, Castilla y Leon, 09400, Spain|Novartis Investigative Site, Miranda de Ebro, Castilla y Leon, 09200, Spain|Novartis Investigative Site, Barcelona, Catalunya, 08025, Spain|Novartis Investigative Site, Barcelona, Cataluña, 08025, Spain|Novartis Investigative Site, Barcelona, Cataluña, 08905, Spain|Novartis Investigative Site, Girona, Cataluña, 17007, Spain|Novartis Investigative Site, La Pobla Llarga, Cataluña, 46670, Spain|Novartis Investigative Site, Llança, Cataluña, 17490, Spain|Novartis Investigative Site, Manresa, Cataluña, 08240, Spain|Novartis Investigative Site, Mollet del Vallés, Cataluña, 08100, Spain|Novartis Investigative Site, Rubi, Cataluña, 08191, Spain|Novartis Investigative Site, Santa Coloma de Gramanet, Cataluña, 08923, Spain|Novartis Investigative Site, Tarrega, Cataluña, 25300, Spain|Novartis Investigative Site, Vic, Cataluña, 08500, Spain|Novartis Investigative Site, Alacuas, Comunidad Valenciana, 46970, Spain|Novartis Investigative Site, Alicante, Comunidad Valenciana, 03004, Spain|Novartis Investigative Site, Alzira, Comunidad Valenciana, 46600, Spain|Novartis Investigative Site, Benidorm, Comunidad Valenciana, 03550, Spain|Novartis Investigative Site, Puerto de Sagunto, Comunidad Valenciana, 46520, Spain|Novartis Investigative Site, Quart de Poblet, Comunidad Valenciana, 46930, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46010, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46011, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46014, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46017, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46019, Spain|Novartis Investigative Site, Xixona, Comunidad Valenciana, 03100, Spain|Novartis Investigative Site, Mérida, Extremadura, 06800, Spain|Novartis Investigative Site, Begonte, Galicia, 27373, Spain|Novartis Investigative Site, Ferrol, Galicia, 15405, Spain|Novartis Investigative Site, La Coruña, Galicia, 15010, Spain|Novartis Investigative Site, Pontevedra, Galicia, 36071, Spain|Novartis Investigative Site, Santiago de Compostela, Galicia, 15706, Spain|Novartis Investigative Site, Vigo, Galicia, 36200, Spain|Novartis Investigative Site, Palma De Mallorca, Islas Baleares, Spain|Novartis Investigative Site, Alcorcón, Madrid, 28922, Spain|Novartis Investigative Site, Arganda del Rey, Madrid, 28500, Spain|Novartis Investigative Site, Civdad Real, Madrid, 13002, Spain|Novartis Investigative Site, Murcia, Madrid, 30007, Spain|Novartis Investigative Site, Plentzia, Pais Vasco, 48620, Spain|Novartis Investigative Site, San Sebastian, Pais Vasco, 20014, Spain|Novartis Investigative Site, Villabona, Pais Vasco, 20150, Spain|Novartis Investigative Site, Zumarraga, Pais Vasco, 20700, Spain|Novartis Investigative Site, Alfaro, Rioja, 26540, Spain|Novartis Investigative Site, Logroño, Rioja, 26005, Spain|Novartis Investigative Site, Hospitalet de Llbregat, 08902, Spain|Novartis Investigative Site, Hospitalet de Llobregat, Spain|Novartis Investigative Site, Madrid, 28034, Spain|Novartis Investigative Site, Madrid, 28035, Spain|Novartis Investigative Site, Madrid, 28040, Spain|Novartis Investigative Site, Madrid, 28041, Spain|Novartis Investigative Site, Madrid, 28046, Spain|Novartis Investigative Site, Madrid, 28770, Spain|Novartis Investigative Site, Göteborg, SE-412 55, Sweden|Novartis Investigative Site, Helsingborg, 251 87, Sweden|Novartis Investigative Site, Karlstad, 651 85, Sweden|Novartis Investigative Site, Malmö, 21152, Sweden|Novartis Investigative Site, Rättvik, 79530, Sweden|Novartis Investigative Site, Stenstorp, SE-521 60, Sweden|Novartis Investigative Site, Uppsala, 751 85, Sweden|Novartis Investigative Site, Varberg, s-432 81, Sweden|Novartis Investigative Site, Estavayer-le-Lac, CH, 1470, Switzerland|Novartis Investigative Site, Ascona, Switzerland|Novartis Investigative Site, Bern, 3010, Switzerland|Novartis Investigative Site, Bolligen, 3065, Switzerland|Novartis Investigative Site, Bruderholz, 4101, Switzerland|Novartis Investigative Site, Fribourg, 1700, Switzerland|Novartis Investigative Site, La Chaux-de-Fonds, 2300, Switzerland|Novartis Investigative Site, Lausanne, 1011, Switzerland|Novartis Investigative Site, Lugano, 6900, Switzerland|Novartis Investigative Site, Lugano, 6903, Switzerland|Novartis Investigative Site, Renens, 1020, Switzerland|Novartis Investigative Site, Schaffhausen, 8200, Switzerland|Novartis Investigative Site, St. Gallen, 9007, Switzerland|Novartis Investigative Site, Winterthur, 8400, Switzerland|Novartis Investigative Site, Zuerich, 8091, Switzerland|Novartis Investigative Site, Yungkang, Tainan, 710, Taiwan|Novartis Investigative Site, Changhua, 500, Taiwan|Novartis Investigative Site, Kaohsiung, 807, Taiwan|Novartis Investigative Site, Niaosong Township, 83301, Taiwan|Novartis Investigative Site, Taichung County, Taiwan|Novartis Investigative Site, Taichung, 40705, Taiwan|Novartis Investigative Site, Taichung, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan|Novartis Investigative Site, Taipei, 114, Taiwan|Novartis Investigative Site, Taipei, Taiwan|Novartis Investigative Site, Bangkok, 10330, Thailand|Novartis Investigative Site, Bangkok, 10400, Thailand|Novartis Investigative Site, Bangkok, 10700, Thailand|Novartis Investigative Site, Chiang Mai, 50200, Thailand|Novartis Investigative Site, Altunizade, 34662, Turkey|Novartis Investigative Site, Ankara, 06100, Turkey|Novartis Investigative Site, Ankara, 06590, Turkey|Novartis Investigative Site, Gaziantep, 27070, Turkey|Novartis Investigative Site, Izmir, 35040, Turkey|Novartis Investigative Site, Izmir, 35340, Turkey|Novartis Investigative Site, Kocaeli, 41380, Turkey|Novartis Investigative Site, High Wycombe, Buckinghamshire, HP11 2TT, United Kingdom|Novartis Investigative Site, Truro, Cornwall, TR1 3LJ, United Kingdom|Novartis Investigative Site, Paignton, Devon, TQ4 5LA, United Kingdom|Novartis Investigative Site, Cornwall, England, PL23 1DT, United Kingdom|Novartis Investigative Site, Welwyn Garden City,, Hertfordshire, AL7 4HQ, United Kingdom|Novartis Investigative Site, Gravesend, Kent, DA1 24JW, United Kingdom|Novartis Investigative Site, Glasgow, Scotland, G12 8TA, United Kingdom|Novartis Investigative Site, East Horsley, Surrey, KT24 6QT, United Kingdom|Novartis Investigative Site, Crawley, West Sussex, RH10 7DX, United Kingdom|Novartis Investigative Site, Bath, BA2 3HT, United Kingdom|Novartis Investigative Site, Cardiff, CF14 4XN, United Kingdom|Novartis Investigative Site, Cardiff, CF5 4AD, United Kingdom|Novartis Investigative Site, Glasgow, G11 6NT, United Kingdom|Novartis Investigative Site, Glasgow, G21 3UW, United Kingdom|Novartis Investigative Site, Irvine, KA12 0AY, United Kingdom|Novartis Investigative Site, Lancashire, FY3 7EN, United Kingdom|Novartis Investigative Site, Lancashire, FY4 3AD, United Kingdom|Novartis Investigative Site, London, NW10 7NS, United Kingdom|Novartis Investigative Site, London, SE1 9RT, United Kingdom|Novartis Investigative Site, London, SW17 0QT, United Kingdom|Novartis Investigative Site, Manchester, M13 9NT, United Kingdom|Novartis Investigative Site, Merseyside, L7 8PX, United Kingdom|Novartis Investigative Site, Rugby, CV21 5 PX, United Kingdom|Novartis Investigative Site, Vale of Glanmorgan, CF63 4AR, United Kingdom|Novartis Investigative Site, Wrexham, LL13 7TD, United Kingdom|Novartis Investigative Site, Caracas, Distrito Capital, 1010, Venezuela|Novartis Investigative Site, Caracas, Distrito Capital, 1020, Venezuela|Novartis Investigative Site, Caracas, Distrito Capital, 1040, Venezuela|Novartis Investigative Site, Caracas, Distrito Capital, 1080-A, Venezuela|Novartis Investigative Site, Caracas, Distrito Capital, 1100, Venezuela|Novartis Investigative Site, Puerto Ordaz, Estado Bolívar, 8050, Venezuela|Novartis Investigative Site, Valencia, Estado Carabobo, 2001, Venezuela|Novartis Investigative Site, Caracas, Estado Miranda, 1060, Venezuela
URL: https://clinicaltrials.gov/show/NCT00549757

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D482 Aliskiren small molecule DB09026 Details