| Outcome Measures: |
Primary: Change in oxidative stress biomarkers levels: superoxide dismutase (SOD), catalase, and malondialdehyde (MDA), ELISA assay (same units), From Baseline and after 8 weeks|Change in pro-inflammatory markers concentrations: tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6), ELISA assay (same units), From Baseline and after 8 weeks|Change in serum levels of homocystein, Detection by fluorescence polarization immunoassay, From Baseline and after 8 weeks|Change in serum levels of von Willebrand factor (vWF), Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Adhesion Molecule 1 (VCAM-1), and fibrinogen, ELISA assay (same units), From Baseline and after 8 weeks|Change in serum levels of Vitamin D and Folic acid, Microparticle enzyme immunoassay (same units), From Baseline and after 8 weeks|Change in Total antioxidant capacity (TAC) level, Results expressed in units μg/ml Trolox equivalents, From Baseline and after 8 weeks|Change in inflammation marker level: high sensitivity CRP, Turbid metric test, From Baseline and after 8 weeks | Secondary: Change in Haemoglobin A1C (HbA1C), HbA1C level will be expressed in %, From Baseline and after 8 weeks|Change in Total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, Clinical biochemistry (colorimetric) tests, and results will be expressed in mmol/L (same units), From Baseline and after 8 weeks|Change in body weight, Weight (kg), From Baseline and after 8 weeks
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