| Trial ID: | L2559 |
| Source ID: | NCT00879710
|
| Associated Drug: |
Simvastatin Or Ezetimibe
|
| Title: |
Effect of Diabetes Mellitus on Cholesterol Metabolism
|
| Acronym: |
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| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT00879710/results
|
| Conditions: |
Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus|Hypercholesterolemia
|
| Interventions: |
DRUG: simvastatin or ezetimibe
|
| Outcome Measures: |
Primary: Changes in LDL Cholesterol, Subjects with T1DM or T2DM were assigned to alternating therapy with simvastatin (40 mg) or ezetimibe (10 mg) for 6 weeks in a crossover design. The data are reported as follows. Subjects with type 1 diabetes mellitus: Simvastatin: Changes in LDL after 6-week therapy with simvastatin (irrespective of the treatment order) Ezetimibe: Changes in LDL after 6-week therapy with ezetimibe (irrespective of the treatment order) Subjects with type 2 diabetes mellitus: Simvastatin: Changes in LDL after 6-week therapy with simvastatin (irrespective of the treatment order) Ezetimibe: Changes in LDL after 6-week therapy with ezetimibe (irrespective of the treatment order), 6 weeks after starting drug therapy | Secondary: Changes in Cholesterol Absorption or Synthesis Rates From the Baseline, Our plan was to measure changes in cholesterol absorption and synthesis rates from the baseline after 6 weeks of statin or ezetimibe therapy., 6 weeks after initiation of drug therapy
|
| Sponsor/Collaborators: |
Sponsor: Medical College of Wisconsin
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| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
57
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| Study Type: |
INTERVENTIONAL
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| Study Designs: |
Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
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| Start Date: |
2008-08
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| Completion Date: |
2013-07
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| Results First Posted: |
2016-04-18
|
| Last Update Posted: |
2020-07-29
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| Locations: |
Medical College of Wisconsin /Froedtert Hospital, Milwaukee, Wisconsin, 53226, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT00879710
|
