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Clinical Trial Details

Trial ID: L2640
Source ID: NCT02461589
Associated Drug: Semaglutide
Title: Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes
Acronym:
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT02461589/results
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: liraglutide|DRUG: placebo
Outcome Measures: Primary: Change in HbA1c (Glycosylated Haemoglobin), Estimated mean change from baseline in HbA1c at week 26. The data were analysed for the "on-treatment until rescue medication" observation period which includes observations recorded at or after date of first dose of trial product and not after the last dose of trial product plus the 7-day visit window or date of initiation of rescue therapy., Week 0, week 26 | Secondary: Change in Fasting Plasma Glucose (FPG), Estimated mean change from baseline in FPG at week 26. The data were analysed for the "on-treatment until rescue medication" observation period which includes observations recorded at or after date of first dose of trial product and not after the last dose of trial product plus the 7-day visit window or date of initiation of rescue therapy., Week 0, Week 26|Body Weight Change, The data were analysed for the "on-treatment until rescue medication" observation period which includes observations recorded at or after date of first dose of trial product and not after the last dose of trial product plus the 7-day visit window or date of initiation of rescue therapy., Week 0, Week 26|Change in Systolic and Diastolic Blood Pressure, The data were analysed for the "on-treatment until rescue medication" observation period which includes observations recorded at or after date of first dose of trial product and not after the last dose of trial product plus the 7-day visit window or date of initiation of rescue therapy., Week 0, Week 26
Sponsor/Collaborators: Sponsor: Novo Nordisk A/S
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE2
Enrollment: 706
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2015-09-21
Completion Date: 2016-10-13
Results First Posted: 2018-01-23
Last Update Posted: 2019-07-31
Locations: Novo Nordisk Investigational Site, Birmingham, Alabama, 35209, United States|Novo Nordisk Investigational Site, Birmingham, Alabama, 35294, United States|Novo Nordisk Investigational Site, Coronado, California, 92118, United States|Novo Nordisk Investigational Site, Lancaster, California, 93534, United States|Novo Nordisk Investigational Site, Riverside, California, 92506, United States|Novo Nordisk Investigational Site, Tustin, California, 92780, United States|Novo Nordisk Investigational Site, Van Nuys, California, 91405, United States|Novo Nordisk Investigational Site, Vista, California, 92083, United States|Novo Nordisk Investigational Site, Walnut Creek, California, 94598, United States|Novo Nordisk Investigational Site, Hartford, Connecticut, 06105, United States|Novo Nordisk Investigational Site, Boca Raton, Florida, 33433, United States|Novo Nordisk Investigational Site, Gainesville, Florida, 32609, United States|Novo Nordisk Investigational Site, Gainesville, Florida, 32653, United States|Novo Nordisk Investigational Site, Hialeah, Florida, 33012, United States|Novo Nordisk Investigational Site, Miami, Florida, 33173, United States|Novo Nordisk Investigational Site, Miami, Florida, 33183, United States|Novo Nordisk Investigational Site, Pembroke Pines, Florida, 33026, United States|Novo Nordisk Investigational Site, Ponte Vedra, Florida, 32081, United States|Novo Nordisk Investigational Site, Atlanta, Georgia, 30342, United States|Novo Nordisk Investigational Site, Marietta, Georgia, 30067, United States|Novo Nordisk Investigational Site, Evanston, Illinois, 60201-2477, United States|Novo Nordisk Investigational Site, Evansville, Indiana, 47714, United States|Novo Nordisk Investigational Site, Newton, Kansas, 67114, United States|Novo Nordisk Investigational Site, Louisville, Kentucky, 40206, United States|Novo Nordisk Investigational Site, Madisonville, Kentucky, 42431, United States|Novo Nordisk Investigational Site, Marrero, Louisiana, 70072, United States|Novo Nordisk Investigational Site, Slidell, Louisiana, 70458, United States|Novo Nordisk Investigational Site, Slidell, Louisiana, 70461-4231, United States|Novo Nordisk Investigational Site, Rockville, Maryland, 20852, United States|Novo Nordisk Investigational Site, Boston, Massachusetts, 02215, United States|Novo Nordisk Investigational Site, Buckley, Michigan, 49620, United States|Novo Nordisk Investigational Site, Belzoni, Mississippi, 39038, United States|Novo Nordisk Investigational Site, Bridgeton, Missouri, 63044, United States|Novo Nordisk Investigational Site, Kalispell, Montana, 59901, United States|Novo Nordisk Investigational Site, Elkhorn, Nebraska, 68022, United States|Novo Nordisk Investigational Site, Las Vegas, Nevada, 89103, United States|Novo Nordisk Investigational Site, Lawrenceville, New Jersey, 08648, United States|Novo Nordisk Investigational Site, Hopewell Junction, New York, 12553, United States|Novo Nordisk Investigational Site, Statesville, North Carolina, 28625, United States|Novo Nordisk Investigational Site, Cincinnati, Ohio, 45219, United States|Novo Nordisk Investigational Site, Cincinnati, Ohio, 45227, United States|Novo Nordisk Investigational Site, Cincinnati, Ohio, 45255, United States|Novo Nordisk Investigational Site, Delaware, Ohio, 43015, United States|Novo Nordisk Investigational Site, Dublin, Ohio, 43016, United States|Novo Nordisk Investigational Site, Kettering, Ohio, 45429, United States|Novo Nordisk Investigational Site, Mason, Ohio, 45040-6815, United States|Novo Nordisk Investigational Site, Oklahoma City, Oklahoma, 73112, United States|Novo Nordisk Investigational Site, Corvallis, Oregon, 97330-3737, United States|Novo Nordisk Investigational Site, Downingtown, Pennsylvania, 19335-2620, United States|Novo Nordisk Investigational Site, Media, Pennsylvania, 19063, United States|Novo Nordisk Investigational Site, Smithfield, Pennsylvania, 15478, United States|Novo Nordisk Investigational Site, Uniontown, Pennsylvania, 15401, United States|Novo Nordisk Investigational Site, Charleston, South Carolina, 29412, United States|Novo Nordisk Investigational Site, Hodges, South Carolina, 29653, United States|Novo Nordisk Investigational Site, Indian Land, South Carolina, 29707, United States|Novo Nordisk Investigational Site, Mount Pleasant, South Carolina, 29464, United States|Novo Nordisk Investigational Site, Bristol, Tennessee, 37620-7352, United States|Novo Nordisk Investigational Site, Chattanooga, Tennessee, 37404, United States|Novo Nordisk Investigational Site, Johnson City, Tennessee, 37604, United States|Novo Nordisk Investigational Site, Kingsport, Tennessee, 37660, United States|Novo Nordisk Investigational Site, Memphis, Tennessee, 38119-4806, United States|Novo Nordisk Investigational Site, Nashville, Tennessee, 37203, United States|Novo Nordisk Investigational Site, Arlington, Texas, 76012-4637, United States|Novo Nordisk Investigational Site, Austin, Texas, 78705, United States|Novo Nordisk Investigational Site, Carrollton, Texas, 75010, United States|Novo Nordisk Investigational Site, Dallas, Texas, 75220, United States|Novo Nordisk Investigational Site, Dallas, Texas, 75230, United States|Novo Nordisk Investigational Site, Dallas, Texas, 75251, United States|Novo Nordisk Investigational Site, Dallas, Texas, 75390-9302, United States|Novo Nordisk Investigational Site, Houston, Texas, 77008, United States|Novo Nordisk Investigational Site, Missouri City, Texas, 77459, United States|Novo Nordisk Investigational Site, New Braunfels, Texas, 78130, United States|Novo Nordisk Investigational Site, San Antonio, Texas, 78230, United States|Novo Nordisk Investigational Site, San Antonio, Texas, 78258, United States|Novo Nordisk Investigational Site, Sugar Land, Texas, 77479, United States|Novo Nordisk Investigational Site, Waco, Texas, 76710, United States|Novo Nordisk Investigational Site, Bountiful, Utah, 84010, United States|Novo Nordisk Investigational Site, Clinton, Utah, 84015, United States|Novo Nordisk Investigational Site, Riverton, Utah, 84065, United States|Novo Nordisk Investigational Site, Richmond, Virginia, 23219, United States|Novo Nordisk Investigational Site, Virginia Beach, Virginia, 23454, United States|Novo Nordisk Investigational Site, Winchester, Virginia, 22601, United States|Novo Nordisk Investigational Site, Renton, Washington, 98057, United States|Novo Nordisk Investigational Site, Spokane, Washington, 99216-1557, United States|Novo Nordisk Investigational Site, Graz, 8010, Austria|Novo Nordisk Investigational Site, Saint Stefan, 8511, Austria|Novo Nordisk Investigational Site, Wien, 1130, Austria|Novo Nordisk Investigational Site, Coquitlam, British Columbia, V3K 3P4, Canada|Novo Nordisk Investigational Site, Moncton, New Brunswick, E1G 1A7, Canada|Novo Nordisk Investigational Site, Hamilton, Ontario, L8K 3P3, Canada|Novo Nordisk Investigational Site, Hamilton, Ontario, L8M 1K7, Canada|Novo Nordisk Investigational Site, Sarnia, Ontario, N7T 4X3, Canada|Novo Nordisk Investigational Site, Strathroy, Ontario, N7G 1Y7, Canada|Novo Nordisk Investigational Site, Laval, Quebec, H7T 2P5, Canada|Novo Nordisk Investigational Site, Pointe Claire, Quebec, H9R 4S3, Canada|Novo Nordisk Investigational Site, Benesov, 25601, Czechia|Novo Nordisk Investigational Site, Brno, 602 00, Czechia|Novo Nordisk Investigational Site, Liberec, 46001, Czechia|Novo Nordisk Investigational Site, Nachod, 54701, Czechia|Novo Nordisk Investigational Site, Plzeň, 301 00, Czechia|Novo Nordisk Investigational Site, Police nad Metuji, 54954, Czechia|Novo Nordisk Investigational Site, Praha 4, 140 46, Czechia|Novo Nordisk Investigational Site, Praha 5, 150 00, Czechia|Novo Nordisk Investigational Site, Trutnov, 541 01, Czechia|Novo Nordisk Investigational Site, Eisenach, 99817, Germany|Novo Nordisk Investigational Site, Friedrichsthal, 66299, Germany|Novo Nordisk Investigational Site, Hamburg, 22607, Germany|Novo Nordisk Investigational Site, Münster, 48145, Germany|Novo Nordisk Investigational Site, Pohlheim, 35415, Germany|Novo Nordisk Investigational Site, Rehlingen-Siersburg, 66780, Germany|Novo Nordisk Investigational Site, Saint Ingbert-Oberwürzbach, 66386, Germany|Novo Nordisk Investigational Site, Stuttgart, 70378, Germany|Novo Nordisk Investigational Site, Sulzbach-Rosenberg, 92237, Germany|Novo Nordisk Investigational Site, Klang, Selangor, 41200, Malaysia|Novo Nordisk Investigational Site, Kota Bharu, 15586, Malaysia|Novo Nordisk Investigational Site, Penang, 10450, Malaysia|Novo Nordisk Investigational Site, Seremban, 70300, Malaysia|Novo Nordisk Investigational Site, Seri Manjung, 32040, Malaysia|Novo Nordisk Investigational Site, Dzerzhinskiy, 140091, Russian Federation|Novo Nordisk Investigational Site, Kazan, 420073, Russian Federation|Novo Nordisk Investigational Site, Saint-Petersburg, 191119, Russian Federation|Novo Nordisk Investigational Site, Saratov, 410031, Russian Federation|Novo Nordisk Investigational Site, Saratov, 410039, Russian Federation|Novo Nordisk Investigational Site, Smolensk, 214031, Russian Federation|Novo Nordisk Investigational Site, Syktyvkar, 167981, Russian Federation|Novo Nordisk Investigational Site, Voronezh, 394018, Russian Federation|Novo Nordisk Investigational Site, Belgrade, 11000, Serbia|Novo Nordisk Investigational Site, Kragujevac, 34000, Serbia|Novo Nordisk Investigational Site, Nis, 18000, Serbia|Novo Nordisk Investigational Site, Novi Sad, 21000, Serbia|Novo Nordisk Investigational Site, Zajecar, 19000, Serbia|Novo Nordisk Investigational Site, Bloemfontein, Free State, 9301, South Africa|Novo Nordisk Investigational Site, Johannesburg, Gauteng, 1812, South Africa|Novo Nordisk Investigational Site, Midrand, Gauteng, 1685, South Africa|Novo Nordisk Investigational Site, Durban, KwaZulu-Natal, 4092, South Africa|Novo Nordisk Investigational Site, Durban, KwaZulu-Natal, 4450, South Africa|Novo Nordisk Investigational Site, Middleburg, Mpumalanga, 1055, South Africa|Novo Nordisk Investigational Site, Basingstoke, RG24 9GT, United Kingdom|Novo Nordisk Investigational Site, Belfast, BT16 1RH, United Kingdom|Novo Nordisk Investigational Site, Bexhill-on-Sea, TN39 4SP, United Kingdom|Novo Nordisk Investigational Site, Blackburn, BB2 1AX, United Kingdom|Novo Nordisk Investigational Site, Bristol, BS10 5NB, United Kingdom|Novo Nordisk Investigational Site, Chesterfield, Derbyshire, S40 4AA, United Kingdom|Novo Nordisk Investigational Site, Devon, EX2 5DW, United Kingdom|Novo Nordisk Investigational Site, Harrogate, North Yorkshire, HG2 7SX, United Kingdom|Novo Nordisk Investigational Site, Hinckley, LE10 2SE, United Kingdom|Novo Nordisk Investigational Site, Oxford, OX3 7LE, United Kingdom|Novo Nordisk Investigational Site, Plymouth, PL8 8DQ, United Kingdom|Novo Nordisk Investigational Site, Sidcup, DA14 6LT, United Kingdom|Novo Nordisk Investigational Site, Truro, TR1 3LJ, United Kingdom
URL: https://clinicaltrials.gov/show/NCT02461589

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress