| Trial ID: | L2651 |
| Source ID: | NCT00951392
|
| Associated Drug: |
Euglycemic Hyperinsulinemic Clamp
|
| Title: |
Implication of Metabolic and Genomic Modifications in Elderly Subjects
|
| Acronym: |
COMPALICLAMP
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Insulin Sensitivity|Aging
|
| Interventions: |
DRUG: euglycemic hyperinsulinemic clamp|PROCEDURE: muscle biopsy|DEVICE: indirect calorimetry
|
| Outcome Measures: |
Primary: Comparison of metabolic profile (lipid metabolism and energy expenditure) and insulin sensitivity based on the aging quality, 120 minutes | Secondary: Gene expression in muscle tissue by quantitative RT-PCR: genes involved in the carbohydrates and lipids metabolism (lipid carriers, PPARs), 7 sirtuins isoforms and of their target genes (NFkB, PGC1a), one day|Gene expression in muscle tissue by Global transcriptome analysis by DNA Chip, one day
|
| Sponsor/Collaborators: |
Sponsor: Hospices Civils de Lyon
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
35
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2009-05
|
| Completion Date: |
2009-11
|
| Results First Posted: |
|
| Last Update Posted: |
2019-05-28
|
| Locations: |
Centre de recherche en nutrition humaine Rhône-Alpes, Pierre-Bénite, 69495, France
|
| URL: |
https://clinicaltrials.gov/show/NCT00951392
|
