| Trial ID: | L2831 |
| Source ID: | NCT04314167
|
| Associated Drug: |
Lowering Cholesterol Concentrations By Pcsk-9 Inhibitor
|
| Title: |
Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
|
| Acronym: |
|
| Status: |
TERMINATED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Hypercholesterolemia|Insulin Resistance|Insulin Secretion
|
| Interventions: |
DRUG: Lowering cholesterol concentrations by PCSK-9 inhibitor
|
| Outcome Measures: |
Primary: Change in insulin secretion., Effect of lowering LDL cholesterol levels on insulins secretion.This will be quantified in half of the patients by a hyperglycemic clamp and in the other half by a 75 g oral glucose tolerance test (randomized assignment)., before and after 12 weeks of treatment with a PCSK9-inhibitor. | Secondary: Change in insulin sensitivity., Effect of lowering LDL cholesterol levels on insulin sensitivity. This will be quantified in half of the patients by a hyperglycemic clamp and in the other half by a 75 g oral glucose tolerance test (randomized assignment)., before and after 12 weeks of treatment with a PCSK9-inhibitor.|Change in insulin clearance., Effect of of lowering LDL cholesterol levels on insulin clearance.This will be quantified in half of the patients by a hyperglycemic clamp and in the other half by a 75 g oral glucose tolerance test (randomized assignment)., before and after 12 weeks of treatment with a PCSK9-inhibitor.|Change in glucose tolerance., Effect of lowering LDL cholesterol levels on glucose tolerance assessed by 75g oral glucose tolerance test, before and after 12 weeks of treatment with a PCSK9-inhibitor.
|
| Sponsor/Collaborators: |
Sponsor: University Hospital Tuebingen
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
9
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2020-07-28
|
| Completion Date: |
2024-03-01
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| Results First Posted: |
|
| Last Update Posted: |
2024-05-16
|
| Locations: |
University of Tuebingen, Department of Internal Medicine IV, Tuebingen, 72076, Germany
|
| URL: |
https://clinicaltrials.gov/show/NCT04314167
|
