| Outcome Measures: |
Primary: Beta-cell function, Beta-cell function (disposition index) as measured during an intravenous glucose tolerance test (By Bergman Minimal Model), after 12 weeks of intervention|LVEF, Changes in LVEF assessed by dobutamine stress echocardiography, after 12 weeks of intervention | Secondary: Glucagon, incretin, glucose, NEFA, insulin and C-peptide response during meal test, Baseline (week 0), week 12, week 14, week 26|Insulin sensitivity (Si), acute insulin and C-peptide response to intravenous glucose (AIRg, ACRg), glucose clearance (Kg), glucose effectiveness (Sg) and hepatic extraction of insulin (HEXi), Insulin sensitivity (Si), acute insulin and C-peptide response to intravenous glucose (AIRg, ACRg), glucose clearance (Kg), glucose effectiveness (Sg) and hepatic extraction of insulin (HEXi) derived from a standard frequent sampling intravenous glucose tolerance test (FSIGT, Minimal model), Baseline (week 0), week 12, week 14, week 26|CRP, TNF-alfa and IL-6 in plasma and gene expression of IL6 and TNF-alfa in subcutaneous fat, Baseline (week 0), week 12, week 14, week 26|Non esterified fatty acids (NEFA), NEFA during FSIGT by use of NEFA minimal model, Baseline (week 0), week 12, week 14, week 26|Heart rate variability (HRV), HRV i.e. SDNN (standard deviation of all normal RR interval) assessed during HOLTER monitoring, Baseline (week 0), week 12, week 14, week 26|Maximal velocity of the myocardium in systole (s´) and in diastole (e´), Maximal velocity of the myocardium in systole (s´) and in diastole (e´) during the dobutamine stress test, Baseline (week 0), week 12, week 14, week 26|Changes in exercise tolerance test variables: Total exercise duration (sec), time to limiting angina (sec) and time to 1 mm ST-segment depression (sec), Changes in exercise tolerance test variables: Total exercise duration (sec), time to limiting angina (sec) and time to 1 mm ST-segment depression (sec), Baseline (week 0), week 12, week 14, week 26|ST-depression and ectopic activity, ST-depression and ectopic activity assessed during 24h HOLTER monitoring, Baseline (week 0), week 12, week 14, week 26|Diurnal blood pressure, Baseline (week 0), week 12, week 14, week 26|Diastolic heart function (E/E*), Diastolic heart function (E/E\*) in rest and during stress, Baseline (week 0), week 12, week 14, week 26
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