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Clinical Trial Details

Trial ID: L3149
Source ID: NCT00639457
Associated Drug: Pioglitazone
Title: Exercise and Pioglitazone for HIV-Metabolic Syndromes
Acronym:
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT00639457/results
Conditions: HIV Infections|Type 2 Diabetes|Obesity|HIV|AIDS|Cardiovascular Disease|Lipodystrophy
Interventions: DRUG: Pioglitazone|BEHAVIORAL: Exercise training
Outcome Measures: Primary: Insulin-stimulated Glucose Disposal Rate, Insulin-mediated glucose disposal rate per kg of fat free mass per min, Baseline and week16 | Secondary: Visceral Fat Volume, Baseline and week 16|Abdominal Subcutaneous Fat Volume, Baseline and week 16|Hepatic Lipid Content, Baseline and week 16|Hepatic Glucose Production Rate, ability of insulin to suppress hepatic glucose production = hepatic insulin sensitivity, Baseline and week 16|Serum Lipid and Lipoprotein Levels, Baseline and week 16|Liver Enzyme Levels, Baseline and week 16|Hemoglobin, Baseline and Week 16|Hematocrit, Percentage of blood volume that is red cells, Baseline and Week 16|Serum Adiponectin Levels, Baseline and week 16|Myocardial Contractility, E/A ratio; ratio of the early (E) to late (A) ventricular filling velocities, Baseline and week 16|Myocardial Contractility-LV Ejection Time, Time required to empty the left ventricle into the aorta, Baseline and week 16|Myocardial Contractility-DT, Deceleration time; time from the peak of early diastolic filling to baseline, Baseline and week 16|Myocardial Contractility-SBP, Systolic blood pressure; peak vascular pressure during ventricular contraction, Baseline and week 16|Myocardial Contractility-DBP, Diastolic blood pressure; vascular pressure during ventricular relaxation (diastole), Baseline and week 16
Sponsor/Collaborators: Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases:
Enrollment: 44
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2005-01
Completion Date: 2009-12
Results First Posted: 2013-09-12
Last Update Posted: 2013-10-23
Locations: Washington University School of Medicine, St. Louis, Missouri, 63110, United States
URL: https://clinicaltrials.gov/show/NCT00639457