| Trial ID: | L3246 |
| Source ID: | NCT01660386
|
| Associated Drug: |
Sitagliptin
|
| Title: |
Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"
|
| Acronym: |
|
| Status: |
UNKNOWN
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes
|
| Interventions: |
DRUG: Sitagliptin|DRUG: Saxagliptin|DRUG: Glimepiride|DRUG: Blank control
|
| Outcome Measures: |
Primary: The acute phase and second phase of insulin secretion and C peptide secretion, The primary outcome measures are improvement in beta cell function measured as insulin secretion and C-peptide secretion during the bi-phase hyperglycaemic clamp. The first phase of insulin and C-peptide secretion is defined as the secretion between 0-10min, the second phase is defined as secretion between 20-90min of bi-phase hyperglycaemic clamp, 1-2 months | Secondary: Alpha cell function,GLP-1 response, The secondary outcome measures are a relative increase in glucagon concentration which indicates alpha cell function and the GLP-1 response, DPP-4 activity and before taken the medicine and in 0, 10, 90,150,160,240min during the bi-phase hyperglycaemic clamp., 1-2 months
|
| Sponsor/Collaborators: |
Sponsor: Shanghai Jiao Tong University School of Medicine
|
| Gender: |
MALE
|
| Age: |
ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
12
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
|
| Start Date: |
2012-07
|
| Completion Date: |
2013-03
|
| Results First Posted: |
|
| Last Update Posted: |
2012-12-17
|
| Locations: |
Shanghai Jiao Tong University School of Medicine, Shanghai, 200021, China
|
| URL: |
https://clinicaltrials.gov/show/NCT01660386
|
