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Clinical Trial Details

Trial ID: L3359
Source ID: NCT05564039
Associated Drug: Tirzepatide
Title: A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH)
Acronym: SURPASS-SWITCH
Status: COMPLETED
Study Results: NO
Results:
Conditions: Type 2 Diabetes
Interventions: DRUG: Tirzepatide|DRUG: Dulaglutide
Outcome Measures: Primary: Change from Baseline in Hemoglobin A1c (HbA1c), Baseline, Week 40 | Secondary: Change from Baseline in Weight, Baseline, Week 40|Percentage of Participants Who Achieve HbA1c <7%, Baseline to Week 40|Percentage of Participants Who Achieve HbA1c ≤6.5%, Baseline to Week 40|Percentage of Participants Who Achieve HbA1c <5.7%, Baseline to Week 40|Percentage of Participants Who Achieve Weight loss from Baseline of ≥5%, Baseline to Week 40|Percentage of Participants Who Achieve Weight loss from baseline of ≥10%, Baseline to Week 40|Percentage of Participants Who Achieve Weight loss from baseline of ≥15%, Baseline to Week 40|A Composite Endpoint of HbA1c, Weight loss and Hypoglycemia, A composite endpoint defined as HbA1c ≤ 6.5%, weight loss ≥10%, no hypoglycemia, defined as blood glucose (BG) \<54 milligram/deciliter (mg/dL) \<3.0 millimole/liter (mmol/L) and/or severe hypoglycemia, Week 40|Change from Baseline in Fasting Serum Glucose (FSG), Baseline, Week 40|Change from Baseline in Waist Circumference, Baseline, Week 40|Change from Baseline in Body Mass Index (BMI), Baseline, Week 40|Change from Baseline in Impact of Weight on Quality of Life Clinical Trials Version (IWQOL-Lite CT) - Physical Functioning Score, Baseline, Week 40
Sponsor/Collaborators: Sponsor: Eli Lilly and Company
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 282
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2022-11-30
Completion Date: 2024-08-12
Results First Posted:
Last Update Posted: 2024-08-16
Locations: ALL Medical Research, LLC, Cooper City, Florida, 33024, United States|Metabolic Research Institute, Inc., West Palm Beach, Florida, 33401, United States|NorthShore University Health System, Skokie, Illinois, 60077, United States|Iowa Diabetes and Endocrinology Research Center, West Des Moines, Iowa, 50265, United States|Clinvest Research LLC, Springfield, Missouri, 65807, United States|Alliance for Multispecialty Research, LLC, Norman, Oklahoma, 73069, United States|Juno Research, Houston, Texas, 77040, United States|Biopharma Informatic, LLC, Houston, Texas, 77043, United States|Juno Research, Houston, Texas, 77054, United States|Southern Endocrinology Associates, Mesquite, Texas, 75149, United States|North Hills Family Medicine/North Hills Medical Research, North Richland Hills, Texas, 76180, United States|Imelda General Hospital, Bonheiden, Antwerpen, 2820, Belgium|Antwerp University Hospital, Edegem, Antwerpen, 2650, Belgium|AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium|ZNA Jan Palfijn, Merksem, Vlaams Gewest, 2170, Belgium|UZ Leuven, Leuven, Vlaams-Brabant, 3000, Belgium|Az Damiaan vzw, Oostende, West-Vlaanderen, 8400, Belgium|Medizinisches Versorgungszentrum am Bahnhof Spandau, Spandau, Berlin, 13597, Germany|InnoDiab Forschung Gmbh, Essen, Nordrhein-Westfalen, 45136, Germany|Institut für Diabetesforschung GmbH Münster, Münster, Nordrhein-Westfalen, 48145, Germany|Studienzentrum Dr. Tasso Bieler, Riesa, Sachsen, 01589, Germany|RED-Institut GmbH, Oldenburg, Schleswig-Holstein, 23758, Germany|Diabeteszentrum Hamburg West, Hamburg, 22607, Germany|Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares, Mexico City, Distrito Federal, 11650, Mexico|Diseno y Planeacion en Investigacion Medica, Guadalajara, Jalisco, 44130, Mexico|Unidad de Investigación Clínica y Atención Médica HEPA, Guadalajara, Jalisco, 44670, Mexico|Instituto de Diabetes, Obesidad y Nutricion, Cuernavaca, Morelos, 62250, Mexico|Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo León, 64460, Mexico|Unidad biomedica avanzada monterrey, Monterrey, Nuevo León, 64460, Mexico|Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo León, 66460, Mexico|Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, Ciudad Madero, Tamaulipas, 89440, Mexico|Investigacion En Salud Y Metabolismo Sc, Chihuahua, 31217, Mexico|Diabdana, Oradea, Bihor, 410147, Romania|Mariodiab Clinic, Brasov, Brașov, 500097, Romania|Geea Medical Easy Diet, Bucharest, București, 010627, Romania|Gama Diamed, Mangalia, Constanța, 905500, Romania|CMI DNBM Dr. Pop Lavinia, Baia Mare, Maramureș, 430222, Romania|Clinica Korall, Satu Mare, 440055, Romania
URL: https://clinicaltrials.gov/show/NCT05564039

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress