| Trial ID: | L3470 |
| Source ID: | NCT04133922
|
| Associated Drug: |
Glp-1
|
| Title: |
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
|
| Acronym: |
KML001
|
| Status: |
WITHDRAWN
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 1 Diabetes|Insulin Sensitivity/Resistance
|
| Interventions: |
DRUG: GLP-1|DRUG: Insulin|DRUG: Dextrose 20 % in Water
|
| Outcome Measures: |
Primary: change in microvascular blood volume between baseline and 2 hour insulin clamp, vascular measurement, baseline and after 2 hour insulin clamp|change in insulin sensitivity between baseline and 2 hour insulin clamp, vascular measurement, baseline and after 2 hour insulin clamp | Secondary: change in augmentation index between baseline and 2 hour insulin clamp, vascular measurement, baseline and after 2 hour insulin clamp|change in flow-mediated dilation between baseline and 2 hour insulin clamp, vascular measurement, baseline and after 2 hour insulin clamp|change in pulse wave velocity between baseline and 2 hour insulin clamp, vascular measurement, baseline and after 2 hour insulin clamp
|
| Sponsor/Collaborators: |
Sponsor: University of Virginia | Collaborators: American Diabetes Association|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
| Gender: |
ALL
|
| Age: |
ADULT
|
| Phases: |
EARLY_PHASE1
|
| Enrollment: |
0
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2019-10-14
|
| Completion Date: |
2024-10
|
| Results First Posted: |
|
| Last Update Posted: |
2022-03-22
|
| Locations: |
University of Virginia, Charlottesville, Virginia, 22906, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT04133922
|
