| Outcome Measures: |
Primary: plasma glucose, Postprandial plasma glucose (PG) excursion (AUC240 min), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes | Secondary: Postprandial responses of glucagon-like peptide-1 (GLP-1), Meal response of GLP-1, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of glucose-dependent insulinotropic polypeptide (GIP), Meal response of glucose-dependent insulinotropic polypeptide (GIP), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of glucagon-like peptide-2 (GLP-2), Meal response of glucagon-like peptide-2 (GLP-2), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of Glucagon, Meal response of Glucagon, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of peptide YY (PYY), Meal response of peptide YY (PYY), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of Insulin and c-peptide, Meal response of Insulin and c-peptide as a insulin/c-peptide ratio, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of Ghrelin, Meal response of Ghrelin, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of fibroblast growth factor (FGF)-19, Meal response of fibroblast growth factor (FGF)-19, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of fibroblast growth factor (FGF)-21, Meal response of fibroblast growth factor (FGF)-21, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of Bile acids, Meal response of Bile acids, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of cholecystokinin (CCK), Meal response of cholecystokinin (CCK), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of plasma lipids, Meal response of plasma lipids, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Postprandial responses of Amino acids, Meal response of Amino acids, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Gastric emptying, Gastric emptying measured by paracetamol absorption test. Paracetamol is ingested along with meal, the appearance in blood will be calculated as a measure of gastric emptying., -30 minutes to 240 minutes with ingestion of a meal and paracetamol at 0 minutes|Rate of gall bladder emptying, Gall bladder volumen measured by ultrasound over time after a meal (see time frame below). The rate of gall bladder emptying will be calculated, -30 minutes to 240 minutes with ingestion of a meal at 0 minutes|Liver stiffness and fat, Liver stiffness and fat content measured by fibroscan, At initiation and after 15 days of treatment with sevelamer/placebo|Appetite measured by visual analog scale, We assessed appetite parameters (hunger, satiety, fullness, prospective food consumption) and well-being, nausea, and thirst by visual analogue scales. Overall appetite score (OAS) will be calculated as (satiety + fullness + (100 - hunger) + (100 - prospective food consumption), -30 minutes to 240 minutes with ingestion of a meal at 0 minutes
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