| Trial ID: | L0374 |
| Source ID: | NCT00291720
|
| Associated Drug: |
Spironolactone
|
| Title: |
Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Chronic Kidney Disease|Cardiovascular Disease
|
| Interventions: |
DRUG: Spironolactone|DRUG: Placebo
|
| Outcome Measures: |
Primary: Changes in left ventricular mass on cardiac MRI and arterial stiffness (assessed by pulse wave velocity)., 9 months | Secondary: Changes in aortic distensibility and large vessel augmentation, 9 months
|
| Sponsor/Collaborators: |
Sponsor: University Hospital Birmingham | Collaborators: British Heart Foundation
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2
|
| Enrollment: |
120
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2005-04
|
| Completion Date: |
2007-12
|
| Results First Posted: |
|
| Last Update Posted: |
2008-05-21
|
| Locations: |
University Hospital Birmingham, Birmingham, West Midlands, B15 2TH, United Kingdom
|
| URL: |
https://clinicaltrials.gov/show/NCT00291720
|
